92077-78-6

Basic information

• Product Name: CILAZAPRIL
• Synonyms: Initiss;Justor;Vascase;9-[(1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino]-10-oxo-1,2,3,4,6,7,8,9-oc tahydropyridazino[1,2-a]diazepine-1-carboxylic acid;(1S,9S)-9-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid hydrate;(1S,9S)-9-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]aMino}-1-hydroxy-10-oxo-octahydro-1H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid;Cilazapril Monohydrate (Inhibace);6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylicacid, 9-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]aMino]octahydro-10-oxo-,hydrate (1:1), (1S,9S)-
• CAS NO: 92077-78-6
• Molecular Formula: C22H33N3O6
• Molecular Weight: 435.51
• EINECS: 200-258-5
• Product Categories: Inhibitors
• Mol File: 92077-78-6.mol
• Article Data: 0

Chemical Properties

• Melting Point: 98° (dec)
• Boiling Point: 598.1 °C at 760 mmHg
• Flash Point: 315.5 °C
• Appearance: /
• Vapor Pressure: 3.73E-15mmHg at 25°C
• Solubility: Slightly soluble in water, freely soluble in methanol and in methylene chloride.
• PKA: pKa1 3.3; pKa2 6.4(at 25℃)
• CAS DataBase Reference: CILAZAPRIL(CAS DataBase Reference)
• NIST Chemistry Reference: CILAZAPRIL(92077-78-6)
• EPA Substance Registry System: CILAZAPRIL(92077-78-6)

Safety Data

• Hazardous Substances Data: 92077-78-6(Hazardous Substances Data)

Usage

Description

Cilazapril is a potent and long-lasting angiotensin-converting enzyme (ACE) inhibitor, used in the management of mild to moderate hypertension. It is a prodrug that is de-esterified to its active diacid metabolite cilazaprilat upon oral administration. Cilazapril is characterized by its white or almost white crystalline powder form and exhibits more potency and longer duration of action compared to other ACE inhibitors like enalapril and captopril.

Uses

Used in Pharmaceutical Industry:
Cilazapril is used as an antihypertensive agent for the treatment of mild to moderate hypertension. It functions by inhibiting the angiotensin-converting enzyme, which in turn reduces the production of angiotensin II, a potent vasoconstrictor. This leads to vasodilation, decreased peripheral resistance, and ultimately, a reduction in blood pressure.
The use of Cilazapril in the pharmaceutical industry is primarily for its therapeutic effects in managing hypertension, providing a more potent and longer-lasting alternative to other ACE inhibitors. Its chemical properties and mode of action make it a valuable component in the development of antihypertensive medications.

InChI:InChI=1/C22H31N3O5.H2O/c1-2-30-22(29)18(13-12-16-8-4-3-5-9-16)23-17-10-6-14-24-15-7-11-19(21(27)28)25(24)20(17)26;/h3-5,8-9,17-19,23H,2,6-7,10-15H2,1H3,(H,27,28);1H2/t17-,18-,19-;/m0./s1