921208-39-1

Basic information

• Product Name: tert butyl 4'-[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-ylmethyl]biphenyl-2-carboxylate hydrochloride
• Synonyms: tert butyl 4'-[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-ylmethyl]biphenyl-2-carboxylate hydrochloride
• CAS NO: 921208-39-1
• Molecular Weight: 607.195
• Mol File: 921208-39-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert butyl 4'-[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-ylmethyl]biphenyl-2-carboxylate hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: tert butyl 4'-[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-ylmethyl]biphenyl-2-carboxylate hydrochloride(921208-39-1)
• EPA Substance Registry System: tert butyl 4'-[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-ylmethyl]biphenyl-2-carboxylate hydrochloride(921208-39-1)

Safety Data

• Hazardous Substances Data: 921208-39-1(Hazardous Substances Data)

Upstream product

• 114772-40-6 4'-bromomethyl-biphenyl-2-carboxylic acid tert-butyl ester 
• 152628-02-9 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole 

Relevant articles and documents

A PROCESS FOR THE PREPARATION OF TELMISARTAN

The present invention encompasses a method for the preparation of Telmisartan comprises, through Telmisartan dihydrochloride comprises i) Condensing 4-Methyl-2-n-propyl-lH- benzimidazole-6-carboxylic acid with N-Methyl-O-phenylenediamine dihydrochloride to yields 4-methyl-6 (1 -methyl benzimidazol-2-yl)-2-n-propyl lH-benzimidazole ii) Treating 4- methyl-6-(l -methyl benzimidazol-2-yl)-2-n-propyl-lH-benzimidazole with 4`- (bromomethyl)-2-biphenyl-2-carboxylate in presence of a base in an organic solvent and isolating the ester as acid addition salt iii) Converting ester acid addition salt to Telmisartan dihydrochloride and iv) Converting Telmisartan dihydrochloride to Telmisartan.