92123-05-2

Basic information

• Product Name: 6-chloro-2-phenylthio-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-9H-purine
• Synonyms: 6-chloro-2-phenylthio-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-9H-purine
• CAS NO: 92123-05-2
• Molecular Weight: 520.95
• Mol File: 92123-05-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 6-chloro-2-phenylthio-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-9H-purine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-2-phenylthio-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-9H-purine(92123-05-2)
• EPA Substance Registry System: 6-chloro-2-phenylthio-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-9H-purine(92123-05-2)

Safety Data

• Hazardous Substances Data: 92123-05-2(Hazardous Substances Data)

Upstream product

• 6979-94-8 2',3',5'-tri-O-acetyl-guanosine 
• 118-00-3 G 
• 16321-99-6 2-amino-6-chloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine 
• 882-33-7 diphenyldisulfane 

Downstream Products

• 1379453-77-6 N₆-phenethyl-2-phenylthioadenosine 
• 92123-07-4 Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-(2-benzenesulfonyl-6-methoxy-purin-9-yl)-tetrahydro-furan-3-yl ester 
• 120524-35-8 N⁶-cyclopentyl-2-(phenylsulfonyl)adenosine 2',3',5'-triacetate 
• 120524-38-1 2-(phenylsulfonyl)-N⁶-(1-naphthylmethyl)adenosine 
• 120524-32-5 (2R,3R,4S,5R)-2-[6-(2,2-Diphenyl-ethylamino)-2-phenylsulfanyl-purin-9-yl]-5-hydroxymethyl-tetrahydro-furan-3,4-diol 
• 120524-33-6 (2R,3S,4R,5R)-2-Hydroxymethyl-5-{6-[(naphthalen-1-ylmethyl)-amino]-2-phenylsulfanyl-purin-9-yl}-tetrahydro-furan-3,4-diol 
• 120524-37-0 N⁶-cyclohexyl-2-(phenylsulfonyl)adenosine 
• 120524-36-9 N⁶-cyclopentyl-2-(phenylsulfonyl)adenosine 
• 120524-31-4 (2R,3R,4S,5R)-2-(6-Cyclohexylamino-2-phenylsulfanyl-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol 
• 120524-30-3 (2R,3R,4S,5R)-2-(6-Cyclopentylamino-2-phenylsulfanyl-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol 
• 120524-34-7 6-chloro-2-(phenylsulfonyl)-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-9H-purine 
• 92123-06-3 Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-(6-methoxy-2-phenylsulfanyl-purin-9-yl)-tetrahydro-furan-3-yl ester 

Relevant articles and documents

Essential Structural Profile of Novel Adenosine Derivatives as Antiplatelet Aggregation Inhibitors Based on 3D-QSAR Analysis Using CoMFA, CoMSIA, and SOMFA

Abstact: —In this study, comparative molecular field analysis (CoMFA), comparative molecular similarity indices analysis (CoMSIA), and the self-organizing molecular field analysis (SOMFA) were performed on a series of novel adenosine derivatives. Significant correlation coefficients (CoMFA, q2 = 0.560, r2 = 0.940, F value = 71.850, and SEE = 0.097; CoMSIA, q2 = 0.528, r2 = 0.943, F value = 29.29 and SEE = 0.108; SOMFA, r2 = 0.615, r2cr= 0.577, F value = 60.797, and SEE = 0.226) were obtained, and the generated models were validated using test sets. By analyzing the corresponding contour maps in detail, new adenosine derivatives with potential efficacy were designed for synthesis in the future.

CONVERSION OF GUANOSINE INTO 2-AMINOMETHYLINOSINE (2-HOMOGUANOSINE)

2-Aminomethylinosine (1), a one-carbon extended homolog of an exocyclic amino group of guanosine, was synthesized from guanosine by the use of a newly developed protection and deprotection method.Introduction of a methoxy group into the 6-position of 2-benzenesulfonyl-purine riboside facilitated a nucleophilic substitution with cyanide to afford 2-cyano-6-methoxypurine riboside (11) which was subsequently hydrogenated and demethylated with trimethylsilyl iodide to afford 1.KEYWORDS - 2-substituted purine nucleoside ; 2-homoguanosine; guanosine; cyanation; benzenesulfonyl group; trimethylsilyl iodide; demethylation; non-aqueous diazotization