92144-26-8

Basic information

• Product Name: 6-[(2-benzylpiperidin-1-yl)sulfonyl]quinazoline-2,4-diamine
• CAS NO: 92144-26-8
• Molecular Formula: C₂₀H₂₃N₅O₂S
• Molecular Weight: 397.4939
• Mol File: 92144-26-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 683.4°C at 760 mmHg
• Flash Point: 367.1°C
• Density: 1.379g/cm³
• Vapor Pressure: 1.56E-18mmHg at 25°C
• Refractive Index: 1.69
• CAS DataBase Reference: 6-[(2-benzylpiperidin-1-yl)sulfonyl]quinazoline-2,4-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-[(2-benzylpiperidin-1-yl)sulfonyl]quinazoline-2,4-diamine(92144-26-8)
• EPA Substance Registry System: 6-[(2-benzylpiperidin-1-yl)sulfonyl]quinazoline-2,4-diamine(92144-26-8)

Safety Data

• Hazardous Substances Data: 92144-26-8(Hazardous Substances Data)

Upstream product

• 32838-55-4 2-benzylpiperidine 
• 92144-33-7 2,4-diamino-6-quinazolinesulfonyl chloride sulfate 
• 81080-73-1 2,4-quinazolinediamine sulfate 

Relevant articles and documents

Folate antagonists. 22. Antimalarial and antibacterial effects of 2,4-diamino-6-quinazolinesulfonamides

The synthesis and antimalarial activity of a series of 2,4-diamino-6-quinazolinesulfonamides is described. Chlorosulfonation of 2,4-quinazolinediamine affords the 6-sulfonyl chloride, which upon treatment with the appropriate amine produces the desired products. Alternatively the sulfonyl chloride could be introduced by diazotization of the corresponding amine followed by treatment with SO2 in the presence of CuCl2. Although substantial antimalarial activity was demonstrated for several members of this class, studies were discontinued in light of the potency of related series.