922501-00-6Relevant articles and documents
Oxetanes as promising modules in drug discovery
Wuitschik, Georg,Rogers-Evans, Mark,Mueller, Klaus,Fischer, Holger,Wagner, Bjoern,Schuler, Franz,Polonchuk, Liudmila,Carreira, Erick M.
, p. 7736 - 7739 (2007/10/03)
(Chemical Equation Presented) Ring the changes: Introduction of an oxetane ring results in remarkably improved physico- and biochemical properties of the underlying scaffold. The oxetane ring confers enhanced solubility, reduces the metabolic degredation, lipophilicity, and amphiphilicity, and modulates the basicity of a nearby amine group.