923555-85-5Relevant articles and documents
Synthesis of Aliphatic Carboxamides Mediated by Nickel NN2-Pincer Complexes and Adaptation to Carbon-Isotope Labeling
Neumann, Karoline T.,Donslund, Aske S.,Andersen, Thomas L.,Nielsen, Dennis U.,Skrydstrup, Troels
, p. 14946 - 14949 (2018)
The development of a nickel-mediated aminocarbonylation utilizing NN2-pincer Ni-complexes, alkylzinc reagents, stoichiometric carbon monoxide and amines is described for the first time, which can be adapted to late-stage carbon-isotope labeling. This work expands the scope of the highly established palladium-promoted version of the reaction, by allowing carbon-sp3 fragments to take part in the three-component reaction. Finally, the results obtained show a remarkable effect of the pincer ligand for the reductive elimination step with the amine, which is followed by 13C NMR spectroscopy studies.
