92394-00-8

Basic information

• Product Name: 1-[4-(4-AMINO-PHENYL)-PIPERAZIN-1-YL]-ETHANONE
• Synonyms: 4-(4-ACETYLPIPERAZIN-1-YL)ANILINE;4-(4-ACETYL-1-PIPERAZINYL)ANILINE;AKOS BB-8665;1-ACETYL-4-(4-AMINOPHENYL)PIPERAZINE;1-[4-(4-AMINO-PHENYL)-PIPERAZIN-1-YL]-ETHANONE;LABOTEST-BB LT00654234;ART-CHEM-BB B025630;ASISCHEM Z45856
• CAS NO: 92394-00-8
• Molecular Formula: C₁₂H₁₇N₃O
• Molecular Weight: 219.28
• Product Categories: Amines;Phenyls & Phenyl-Het;Phenyls & Phenyl-Het
• Mol File: 92394-00-8.mol
• Article Data: 29

Chemical Properties

• Boiling Point: 460.7 °C at 760 mmHg
• Flash Point: 232.4 °C
• Appearance: /
• Density: 1.177g/cm³
• Vapor Pressure: 1.14E-08mmHg at 25°C
• Refractive Index: 1.596
• PKA: 7.69±0.10(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 1-[4-(4-AMINO-PHENYL)-PIPERAZIN-1-YL]-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4-(4-AMINO-PHENYL)-PIPERAZIN-1-YL]-ETHANONE(92394-00-8)
• EPA Substance Registry System: 1-[4-(4-AMINO-PHENYL)-PIPERAZIN-1-YL]-ETHANONE(92394-00-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 92394-00-8(Hazardous Substances Data)

Usage

General Description

1-[4-(4-AMINO-PHENYL)-PIPERAZIN-1-YL]-ETHANONE, also known as 1-(4-Amino-phenyl)piperazin-1-yl)ethanone, is a chemical compound with the molecular formula C13H18N4O. It is a piperazinylketone derivative that is commonly used in pharmaceutical research and drug development. 1-[4-(4-AMINO-PHENYL)-PIPERAZIN-1-YL]-ETHANONE has potential application in the treatment of various neurological and psychiatric disorders, including depression, anxiety, and schizophrenia. It acts as a central nervous system stimulant and has been studied for its potential as a psychostimulant and anorectic agent. Additionally, it has been investigated for its potential analgesic and anti-inflammatory properties. Its precise mechanism of action and pharmacological effects are still being explored and studied.

InChI:InChI=1/C12H17N3O/c1-10(16)14-6-8-15(9-7-14)12-4-2-11(13)3-5-12/h2-5H,6-9,13H2,1H3

Upstream product

• 67455-41-8 4-(piperazin-1-yl)aniline 
• 16264-08-7 1-[4-(4-Nitro-phenyl)-piperazinyl]-ethanone 
• 13889-98-0 N-acetylpiperidine 
• 350-46-9 4-Fluoronitrobenzene 
• 6269-89-2 1-(4-Nitrophenyl)piperazine 
• 636-98-6 p-nitrobenzene iodide 
• 586-78-7 para-nitrophenyl bromide 

Downstream Products

• 693230-07-8 N-[4-(4-acetyl-piperazin-1-yl)-phenyl]-guanidine nitrate 
• 442548-36-9 8-(4-Methyl-piperazin-1-yl)-4-oxo-4H-chromene-2-carboxylic acid [4-(4-acetyl-piperazin-1-yl)-phenyl]-amide 
• 442548-84-7 6-Fluoro-8-(4-methyl-piperazin-1-yl)-4-oxo-4H-chromene-2-carboxylic acid [4-(4-acetyl-piperazin-1-yl)-phenyl]-amide 
• 352329-12-5 1-{4-[4-(7-Amino-pyrido[2,3-d]pyrimidin-2-ylamino)-phenyl]piperazin-1-yl}-ethanone 
• 223785-84-0 4-(4-acetyl-piperazin-1-yl)-phenyl isothiocyanate 
• 892491-29-1 methyl {[4-(4-acetylpiperazin-1-yl)phenyl]amino}(oxo)acetate 
• 1122709-88-9 1-(4-(4-(4-(1H-indazol-6-ylamino)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)phenyl)piperazin-1-yl)ethanone 
• 1122709-92-5 1-(4-(4-(4-(3-methyl-1H-indazol-6-ylamino)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)phenyl)piperazin-1-yl)ethanone 
• 1122710-18-2 1-(4-(4-(4-(1H-indazol-6-ylamino)-5-methyl-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)phenyl)piperazin-1-yl)ethanone 
• 1122710-47-7 1-(4-(4-(4-(1H-indazol-4-ylamino)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)phenyl)piperazin-1-yl)ethanone 
• 941319-62-6 N-{3-[3-(2-{[4-(4-Acetyl-1-piperazinyl)phenyl]amino}-4-pyrimidinyl)-6-methylpyrazolo[1,5-a]pyridin-2-yl]phenyl}-2-(2-thienyl)acetamide 
• 1198300-19-4 4-(1H-indazol-6-ylamino)-2-(4-(4-acetylpiperazin-1-yl)phenylamino)pyrimidine-5-carboxamide 
• 1198299-96-5 2-(4-(4-acetylpiperazin-1-yl)phenylamino)-4-(cyclobutylamino)pyrimidine-5-carboxamide 
• 1198300-18-3 2,4-bis(4-(4-acetylpiperazin-1-yl)phenylamino)pyrimidine-5-carboxamide 

Relevant articles and documents

Identification of a Novel 2,8-Diazaspiro[4.5]decan-1-one Derivative as a Potent and Selective Dual TYK2/JAK1 Inhibitor for the Treatment of Inflammatory Bowel Disease

In this study, we described a series of 2,8-diazaspiro[4.5]decan-1-one derivatives as selective TYK2/JAK1 inhibitors. Systematic exploration of the structure-activity relationship through the introduction of spirocyclic scaffolds based on the reported selective TYK2 inhibitor 14l led to the discovery of the superior derivative compound 48. Compound 48 showed excellent potency on TYK2/JAK1 kinases with IC50 values of 6 and 37 nM, respectively, and exhibited more than 23-fold selectivity for JAK2. Compound 48 also demonstrated excellent metabolic stability and more potent anti-inflammatory efficacy than tofacitinib in acute ulcerative colitis models. Moreover, the excellent anti-inflammatory effect of compound 48 was mediated by regulating the expression of related TYK2/JAK1-regulated genes, as well as the formation of Th1, Th2, and Th17 cells. Taken together, these findings suggest that compound 48 is a selective dual TYK2/JAK inhibitor, deserving to be developed as a clinical candidate.

Discovery of novel 4-azaaryl-N-phenylpyrimidin-2-amine derivatives as potent and selective FLT3 inhibitors for acute myeloid leukaemia with FLT3 mutations

Feline McDonough sarcoma (FMS)-like tyrosine kinase 3 (FLT3) is one of the most pursued targets in the treatment of acute myeloid leukaemia (AML) as its gene amplification and mutations, particularly internal tandem duplication (ITD), contribute to the pa

Design, synthesis and SAR study of 2-aminopyrimidines with diverse Michael addition acceptors for chemically tuning the potency against EGFRL858R/T790M

The covalent binding nature of irreversible kinase inhibitors potentially increases the severity of “off-target” toxicity. Based on our continual strategy of chemically tuning the Michael addition acceptors, herein, we further explore the relationship amo