92428-42-7

Basic information

• Product Name: 2-(4-Chlor-styryl)-benzoesaeure
• Synonyms: 2-(4-Chlor-styryl)-benzoesaeure
• CAS NO: 92428-42-7
• Molecular Weight: 258.704
• Mol File: 92428-42-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-(4-Chlor-styryl)-benzoesaeure(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Chlor-styryl)-benzoesaeure(92428-42-7)
• EPA Substance Registry System: 2-(4-Chlor-styryl)-benzoesaeure(92428-42-7)

Safety Data

• Hazardous Substances Data: 92428-42-7(Hazardous Substances Data)

Upstream product

• 637-87-6 1-Chloro-4-iodobenzene 
• 27326-43-8 2-vinylbenzoic acid 
• 7677-24-9 trimethylsilyl cyanide 
• 106-47-8 4-chloro-aniline 
• 119-67-5 o-carboxybenzaldehyde 
• 89-71-4 2-Methyl-benzoic acid methyl ester 
• 1073-67-2 4-vinylbenzyl chloride 
• 38453-73-5 methyl 2-[(E)-2-(4-chlorophenyl)ethenyl]benzoate 
• 38453-65-5 3-(4-chlorobenzyl)isobenzofuran-1(3H)-one 

Downstream Products

• 1354004-82-2 (3S,4R)-4-bromo-3-(4-chlorophenyl)-3,4-dihydroisochromen-1-one 
• 62827-72-9 3-(p-chlorophenyl)-1H-isochromen-1-one 
• 23909-29-7 2-(4-chlorophenyl)-1H-indene 
• 108683-66-5 C₁₅H₁₂Cl₂ 
• 38453-78-0 4'-Chlor-2-hydroxymethyl-trans-stilben 
• 38453-73-5 methyl 2-[(E)-2-(4-chlorophenyl)ethenyl]benzoate 

Relevant articles and documents

Synthesis and Anti-Influenza Virus Effects of Novel Substituted Polycyclic Pyridone Derivatives Modified from Baloxavir

In this work, a series of novel substituted polycyclic pyridone derivatives were designed and synthesized as potent anti-influenza agents. The cytopathic effect (CPE) assay and cytotoxicity assay indicated that all of the compounds possessed potent anti-influenza virus activity and relatively low cytotoxicity; some of them inhibited the replication of influenza A virus (IAV) at picomolar concentrations. Further studies revealed that, at a concentration of 3 nM, three compounds (10a, 10d, and 10g) could significantly reduce the M2 RNA amounts and M2 protein expression of IAV and inhibit the activity of RNA-dependent RNA polymerase (RdRp). Among them, (R)-12-(5H-dibenzo[a,d][7]annulen-5-yl)-7-hydroxy-3,4,12,12a-tetrahydro-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione (10a) was found to be a promising anti-influenza drug candidate with good human liver microsomal stability, as well as with better selectivity index and oral bioavailability than Baloxavir.

A facile and efficient method for the synthesis of N-substituted 3-oxoisoindoline-1-carbonitrile derivatives catalyzed by sulfamic acid

A new and efficient method for the synthesis of N-substituted 3-oxoisoindoline-1-carbonitrile derivatives by a one-pot, three-component condensation reaction of 2-carboxybenzaldehyde, primary amine, and TMSCN in the presence of 10 mol % sulfamic acid (NH2SO3H) as the catalyst in EtOH under reflux temperature is described. The process is simple and environmentally benign and the catalyst is commercially available and inexpensive. ARKAT-USA, Inc.

Asymmetric protonation of ketone enolates using chiral β- hydroxyethers: Acidity-tuned enantioselectivity

New chiral hydroxyethers 1a-f were prepared for asymmetric protonation of achiral enolates prepared from prochiral ketones. The enantioselectivity of protonation was highly dependent upon the acidity of the chiral alcohols, the highest enantioselectivity