92446-30-5

Basic information

• Product Name: 5-hydroxy-4-methoxy-1-methylpyridine-2,6(1H,3H)-dione
• CAS NO: 92446-30-5
• Molecular Formula: C₇H₉NO₄
• Molecular Weight: 171.1507
• Mol File: 92446-30-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 391.8°C at 760 mmHg
• Flash Point: 190.7°C
• Density: 1.38g/cm³
• Vapor Pressure: 9.28E-08mmHg at 25°C
• Refractive Index: 1.547
• CAS DataBase Reference: 5-hydroxy-4-methoxy-1-methylpyridine-2,6(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-hydroxy-4-methoxy-1-methylpyridine-2,6(1H,3H)-dione(92446-30-5)
• EPA Substance Registry System: 5-hydroxy-4-methoxy-1-methylpyridine-2,6(1H,3H)-dione(92446-30-5)

Safety Data

• Hazardous Substances Data: 92446-30-5(Hazardous Substances Data)

Usage

Chemical compound

5-hydroxy-4-methoxy-1-methylpyridine-2,6(1H,3H)-dione

Pharmaceutical drug

Yes

Derived from

Coumarin

Properties

Anti-inflammatory, choleretic

Uses

Inhibit formation and secretion of bile stones, treatment of liver and gallbladder conditions

Potential therapeutic effects

Osteoarthritis, inflammatory bowel disease

Biologically active compound

Yes

Potential pharmaceutical uses

Treatment of various diseases and disorders

Upstream product

• 100009-64-1 4-methoxy-1-methylpyridine-2,6(1H,3H)-dione 
• 92446-35-0 5,5'-dihydroxy-4,4'-dimethoxy-1,1'-dimethyl-3,3'-bipyridine-2,2',6,6'-(1H,1'H,3H,3'H)-tetraone 
• 1830-54-2 3-oxopentanedioic acid dimethyl ester 
• 20414-58-8 3-methoxypent-2-enedioic acid dimethyl ester 

Downstream Products

• 92446-32-7 4-methoxy-1-methylpyridine-2,3,6-trione 

Relevant articles and documents

Lipophilic constituents from aerial and root parts of Mercurialis perennis L

Introduction - Dog's mercury (Mercurialis perennis L.) is a perennial herb used in remedies for medicinal purposes. The plant is supposed to contain potentially active substances but its constituents have only been rarely studied. Objective - Detailed studies on the phytochemical composition are of great interest to broaden the knowledge on the chemotaxonomy and pharmacognosy of M. perennis. Methodology - Chloroform and hexane extracts from roots and aerial parts were investigated using GC/MS and LC/MS. Results - The whole plant exhihited a broad spectrum of structurally diverse constituents, mainly alkaloids, terpenes, sterols and simple aromatic compounds. Closer inspection of the piperidine alkaloid hermidin revealed its inherent instability towards air oxygen. To obtain quantitative data on these alkaloids the synthesis of the more stable reference compound 4-methoxy-1-methylpyridine-2,6(1H,3H)-dione (MMPD) was required. In this study, MMPD was detected for the fi rst time as a genuine compound in Mercurialis. Hermidine quinone and hermidin dimers originating from hermidin via a free anionic radical reaction were also confi rmed by GC/MS. Moreover, volatile compounds such as benzylalcohol, 2-phenylethanol, 4-methoxy- and 3,4-dimethoxyphenol, (-)-cis- and (+)-trans-myrtanol, (-)-cis-myrtanal as well as squalene were predominantely present in Mercurialis roots. In contrast, aerial parts mainly contained phytol derivatives, sterols and tocopherols. By changing solvent polarity, lipid and wax-containing fractions were obtained. LC/MS-studies on hexane extracts showed the presence of several mixed triglycerides constituted by linolenic, linoleic, oleic, stearic and palmitic acids, as well as lutein, carotenes and pheophytins. Conclusions - The phytochemical data presented complement our knowledge on the rarely studied plant M. perennis and may broaden its use in future phytotherapy. Copyright