92455-57-7

Basic information

• Product Name: N^α-(Benzyloxycarbonyl)-N^δ-(t-butoxycarbonyl)-L-ornithine benzyl ester
• Synonyms: N^α-(Benzyloxycarbonyl)-N^δ-(t-butoxycarbonyl)-L-ornithine benzyl ester
• CAS NO: 92455-57-7
• Molecular Weight: 456.539
• Mol File: 92455-57-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N^α-(Benzyloxycarbonyl)-N^δ-(t-butoxycarbonyl)-L-ornithine benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N^α-(Benzyloxycarbonyl)-N^δ-(t-butoxycarbonyl)-L-ornithine benzyl ester(92455-57-7)
• EPA Substance Registry System: N^α-(Benzyloxycarbonyl)-N^δ-(t-butoxycarbonyl)-L-ornithine benzyl ester(92455-57-7)

Safety Data

• Hazardous Substances Data: 92455-57-7(Hazardous Substances Data)

Upstream product

• 2640-58-6 Nα-benzyloxycarbonyl-L-ornithine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 7733-29-1 Z-Orn(Boc)-OH 
• 100-39-0 benzyl bromide 

Downstream Products

• 63446-55-9 N^δ-(Phosphonoacetyl)-L-orinithine 
• 98512-07-3 Z-Orn-OBn 
• 92455-58-8 N^α-(Benzyloxycarbonyl)-N^δ-(dibenzylphosphonoacetyl)-L-ornithine benzyl ester 

Relevant articles and documents

NG-aminoguanidines from primary amines and the preparation of nitric oxide synthase inhibitors

A concise, general, and high-yielding method for the preparation of N G-aminoguanidines from primary amines is reported. Using available and readily prepared materials, primary amines are converted to protected N G-aminoguanidines in a one-pot procedure. The method has been successfully applied to a number of examples including the syntheses of four nitric oxide synthase (NOS) inhibitors. The inhibitors prepared were investigated as competitive inhibitors and as mechanistic inactivators of the inducible isoform of NOS (iNOS). In addition, one of the four inhibitors prepared, NG-amino-NG-2,2,2-trifluoroethyl-L-arginine 19, displays the unique ability to both inhibit NO formation and prevent NADPH consumption by iNOS without irreversible inactivation of the enzyme.

An Improved Synthesis of Nδ-(Phosphonoacetyl)-L-ornithine

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