924660-44-6Relevant articles and documents
Synthesis of 5-methyl phenanthridium derivatives: A new class of human DOPA decarboxylase inhibitors
Cheng, Pi,Zhou, Jie,Qing, Zhixing,Kang, Weisong,Liu, Sheng,Liu, Wei,Xie, Hongqi,Zeng, Jianguo
, p. 2712 - 2716 (2014/06/09)
DOPA decarboxylase (DDC) is responsible for the decarboxylation of l-DOPA and related aromatic amino acids and correlates closely with a number of clinical disorders. Sanguinarine, a natural quaternary benzophenanthridine alkaloid (QBA), was reported to b
Efficient synthesis of phenanthridinone derivatives via a palladium-catalyzed coupling process
Furuta, Takumi,Kitamura, Yuki,Hashimoto, Ayano,Fujii, Satoshi,Tanaka, Kiyoshi,Kan, Toshiyuki
, p. 183 - 186 (2007/10/03)
(Chemical Equation Presented) A palladium-mediated domino reaction was developed to conveniently synthesize phenanthridinone derivatives. Phosphine ligand 1 strongly promotes the domino process, which includes aryl-aryl coupling and C-N bond formations concomitant with a deamidation reaction. The versatility and applicability to a broad range of substrates make this reaction useful for the development of bioactive derivatives.