92472-37-2Relevant articles and documents
Design, synthesis, and biological evaluation of 16-substituted 4-azasteroids as tissue-Selective Androgen Receptor Modulators (SARMs)
Mitchell, Helen J.,Dankulich, William P.,Hartman, George D.,Prueksaritanont, Thomayant,Schmidt, Azriel,Vogel, Robert L.,Bai, Chang,McElwee-Witmer, Sheila,Zhang, Hai Z.,Chen, Fang,Leu, Chih-Tai,Kimmel, Donald B.,Ray, William J.,Nantermet, Pascale,Gentile, Michael A.,Duggan, Mark E.,Meissner, Robert S.
scheme or table, p. 4578 - 4581 (2010/03/02)
A novel series of 16-substituted-4-azasteroids has been identified as potential tissue-selective androgen receptor modulators. These ligands display potenthARbinding and agonist activity, low virilizing potential, and good pharmacokinetic profiles in dogs
17-BETA-CYCLOPROPYL(AMINO/OXY) 4-AZA STEROIDS AS ACTIVE INHIBITORS OF TESTOSTERONE 5-ALPHA-REDUCTASE AND C17-20-LYASE
-
, (2008/06/13)
The invention related to 4-aza-17 beta -(cyclopropoxy)-androst-5 alpha -androstan-3-one, 4-aza-17 beta -(cyclopropylamino)-androst-4-en-3-one and related compounds and to compositions incorporating these compounds, as well as the inhibition of C17-20 lyase, 5 alpha -reductase and C17 alpha -hydroxylase and to the use of these compounds in the treatment of androgen and estrogen mediated disorders, including benign prostatic hyperplasia, androgen mediated prostate cancer, estrogen mediated breast cancer and to DHT-mediated disorders such as acne. Disorders relating to the oversynthesis of cortisol, for example, Cushing's Syndrome, are also included. The treatment of androgen-dependent disorders also includes a combination therapy with known androgen-receptor antagonists, such as flutamide. The compounds of the invention have general formula (I).
Antineoplastic agents. V. Nitrogen mustards of systematically modified steroidal ring A lactams
Dalmases,Cervantes,Quintana,et al.
, p. 465 - 467 (2007/10/02)
The p-[N,N-bis(2-chloroethyl)amino]phenylacetates and p-[N,N-bis(2-chloroethyl)amino]phenoxyacetates of seven 17 β-hydroxylated steroidal ring A lactams have been prepared and their biological activity evaluated against mouse leukemia L1210 and, for four