92524-99-7 Usage
Pyrazole derivative
A compound derived from the pyrazole structure, which is a five-membered heterocyclic ring containing two nitrogen atoms.
Methyl group
A chemical group consisting of one carbon atom bonded to three hydrogen atoms, attached to the nitrogen atom in the compound.
Trimethylsilyl group
A chemical group consisting of one silicon atom bonded to three methyl groups, also attached to the nitrogen atom in the compound.
Intermediate in synthesis
Commonly used as a starting material or building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds.
Potential biological activity
Possesses the ability to interact with biological systems, which may lead to potential applications in the development of novel drugs.
Unique properties from trimethylsilyl group
The presence of the trimethylsilyl group can impart special characteristics to the molecule, making it useful in various research and industrial applications.
Diverse potential uses
1-METHYL-5-TRIMETHYLSILANYL-1H-PYRAZOLE has potential applications in the fields of medicine, agriculture, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 92524-99-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,2,5,2 and 4 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 92524-99:
(7*9)+(6*2)+(5*5)+(4*2)+(3*4)+(2*9)+(1*9)=147
147 % 10 = 7
So 92524-99-7 is a valid CAS Registry Number.
92524-99-7Relevant articles and documents
Access to Silylated Pyrazole Derivatives by Palladium-Catalyzed C?H Activation of a TMS group
Mistico, Laetitia,Querolle, Olivier,Meerpoel, Lieven,Angibaud, Patrick,Durandetti, Muriel,Maddaluno, Jacques
supporting information, p. 9687 - 9692 (2016/07/14)
A simple and efficient approach to new silylated heterocycles of potential interest in medicinal chemistry is presented. A set of bromophenyl trimethylsilyl pyrazole intermediates can be transformed by direct organometallic routes into two families of regioisomeric iodoaryl substrates; using either arylzinc or aryllithium chemistry, the TMS group remains on the pyrazole ring or translocates to the aryl moiety. These two families can then be efficiently transformed into benzo silino pyrazoles thanks to a single-step cyclization relying on the Pd-catalyzed activation of a non-activated C(sp3)?H bond alpha to a silicon atom. The experimental conditions used, which are fully compatible with the pyrazole ring, suggest that this reaction evolves through a concerted metalation–deprotonation (CMD) mechanism.
