92545-95-4

Basic information

• Product Name: 4-Isoxazolecarboxylic acid, 3-(3-chlorophenyl)-5-methyl-
• CAS NO: 92545-95-4
• Molecular Formula: C11H8ClNO3
• Molecular Weight: 237.642
• Mol File: 92545-95-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 395.2±37.0 °C(Predicted)
• Density: 1.385±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 4-Isoxazolecarboxylic acid, 3-(3-chlorophenyl)-5-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Isoxazolecarboxylic acid, 3-(3-chlorophenyl)-5-methyl-(92545-95-4)
• EPA Substance Registry System: 4-Isoxazolecarboxylic acid, 3-(3-chlorophenyl)-5-methyl-(92545-95-4)

Safety Data

• Hazardous Substances Data: 92545-95-4(Hazardous Substances Data)

Upstream product

• 29203-59-6 3-chloro-N-hydroxybenzimidoyl chloride 
• 34158-71-9 3-chlorobenzaldehyde oxime 
• 587-04-2 m-Chlorobenzaldehyde 
• 495417-28-2 3-(3-chloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester 
• 105-45-3 acetoacetic acid methyl ester 

Downstream Products

• 92285-79-5 3-(3-chloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid amide 
• 1159600-23-3 6-[3-(3-chloro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester 
• 1159600-25-5 6-[3-(3-chloro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid 
• 1159600-29-9 {6-[3-(3-chloro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-pyridin-3-yl}-(1,1-dioxo-1λ⁶-thiomorpholin-4-yl)-methanone 
• 495417-32-8 [3-(3-chloro-phenyl)-5-methyl-isoxazol-4-yl]-methanol 

Relevant articles and documents

Synthesis and biological activity of ethyl 2-(5-methyl-3-arylisoxazole-4-carboxamido)-4-alkylthiazole-5-carboxylate

A series of novel ethyl 2-(5-methyl-3-arylisoxazole-4-carboxamido)-4-alkylthiazole-5-carboxylates I-1-6 were synthesized. The structures of all target compounds were characterized by 1H NMR, 13C NMR, IR,MS and elemental analyses. Their fungicidal and herbicidal activities were evaluated. The results of preliminary bioassays show that the title compounds I-4 possess 20-50% inhibition against most of the tested plants at the dosage of 150 g ai/ha, while the title compounds I-1-5 possess 32-58% inhibition against FusaHum graminearum, Thanatephorus cucumeris, Botrytis cinereapers and Fusarium oxysporum in vitro at the concentration of 100 mg/L.

PROCESS FOR THE PREPARATION OF ISOXAZOLYL-METHOXY-NICOTINIC ACIDS

The present invention relates to a process for the preparation of a compound of formula (I) which is useful as an intermediate in the preparation of active pharmaceutical compounds from a compound of formula (IV) wherein R1 and R2 ar

Aminoacetamide acyl guanidines as beta-secretase inhibitors

There is provided a series of substituted acyl guanidines of Formula (Ik) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R2, R3, R4, R5, R25, R26 and R27 as defined herein, their pharmaceutical compositions and methods of use. These compounds inhibit the processing of amyloid precursor protein (APP) by β-secretase and, more specifically, inhibit the production of Aβ-peptide. The present disclosure is directed to compounds useful in the treatment of neurological disorders related to β-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.