925678-00-8

Basic information

• Product Name: 6-chloro-5-iodopyrazin-2-amine
• Synonyms: 6-chloro-5-iodopyrazin-2-amine;6-chloro-5-iodo-2-Pyrazinamine;2-Pyrazinamine, 6-chloro-5-iodo-
• CAS NO: 925678-00-8
• Molecular Formula: C4H3ClIN3
• Molecular Weight: 255.44419
• EINECS: -0
• Mol File: 925678-00-8.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-chloro-5-iodopyrazin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-5-iodopyrazin-2-amine(925678-00-8)
• EPA Substance Registry System: 6-chloro-5-iodopyrazin-2-amine(925678-00-8)

Safety Data

• Hazardous Substances Data: 925678-00-8(Hazardous Substances Data)

Usage

General Description

6-chloro-5-iodopyrazin-2-amine is a chemical compound with the molecular formula C4H3ClIN3. It is a derivative of pyrazine, a heterocyclic aromatic compound, and contains both chlorine and iodine atoms. 6-chloro-5-iodopyrazin-2-amine is commonly used in the field of medicinal chemistry and pharmaceutical research as a building block in the synthesis of various biologically active molecules. It has also been studied for its potential antimicrobial and antifungal properties. Additionally, 6-chloro-5-iodopyrazin-2-amine has been investigated as a potential precursor for the development of novel pharmaceuticals for the treatment of various human diseases. Overall, this chemical compound has shown promise in the field of drug discovery and development due to its diverse range of potential applications.

Upstream product

• 33332-28-4 2-amino-6-chloropyrazine 

Downstream Products

• 1174186-69-6 5,6-di-p-tolylpyrazin-2-amine 
• 34617-65-7 5-amino-3-chloro-pyrazine-2-carbonitrile 

Relevant articles and documents

Discovery, X-ray Crystallography and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B-NS3 Protease

Flaviviruses, including dengue, West Nile and recently emerged Zika virus, are important human pathogens, but there are no drugs to prevent or treat these viral infections. The highly conserved Flavivirus NS2B-NS3 protease is essential for viral replication and therefore a drug target. Compound screening followed by medicinal chemistry yielded a series of drug-like, broadly active inhibitors of Flavivirus proteases with IC50 as low as 120 nM. The inhibitor exhibited significant antiviral activities in cells (EC68: 300-600 nM) and in a mouse model of Zika virus infection. X-ray studies reveal that the inhibitors bind to an allosteric, mostly hydrophobic pocket of dengue NS3 and hold the protease in an open, catalytically inactive conformation. The inhibitors and their binding structures would be useful for rational drug development targeting Zika, dengue and other Flaviviruses.

Synthesis, Structure-Activity Relationships, and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B-NS3 Protease

Flaviviruses, including Zika, dengue, and West Nile viruses, are important human pathogens. The highly conserved NS2B-NS3 protease of Flavivirus is essential for viral replication and therefore a promising drug target. Through compound screening, followed by medicinal chemistry studies, a novel series of 2,5,6-trisubstituted pyrazine compounds are found to be potent, allosteric inhibitors of Zika virus protease (ZVpro) with IC50 values as low as 130 nM. Their structure-activity relationships are discussed. The ZVpro inhibitors also inhibit homologous proteases of dengue and West Nile viruses, and their inhibitory activities are correlated. The most potent compounds 47 and 103 potently inhibited Zika virus replication in cells with EC68 values of 300-600 nM and in a mouse model of Zika infection. These compounds represent novel pharmacological leads for drug development against Flavivirus infections.

HETEROCYCLIC COMPOUNDS AS ADENOSINE ANTAGONISTS

Aminopyrazine compounds as modulators of an adenosine receptor are provided. The compounds may find use as therapeutic agents for the treatment of diseases mediated through a G-protein-coupled receptor signaling pathway and may find particular use in oncology.