92568-81-5Relevant articles and documents
Synthesis and antimicrobial activity of some benzimidazole and 2-methylbenzimidazole derivatives
Jain,Tiwari
, p. 838 - 842 (2017/02/10)
In the present work, benzimidazole and 2-methylbenzimidazole derivatives were synthesized and evaluated for antimicrobial activity against Escherichia coli (Gram-negative bacteria), Staphylococcus aureus (Gram-positive bacteria) and Candida albicans (fungal stain). The structure of the synthesized compounds was confirmed by FTIR, 1H NMR and mass spectroscopy. Antimicrobial activity of all the synthesized compounds was carried out by Broth dilution method to determine MIC value. Compounds P2, P7 and P10 showed better antibacterial activity against Escherichia coli as compared to benzimidazole, 2-methylbenzimidazole and ampicillin. Compounds P8 and P12 showed better antibacterial activity against Staphylococcus aureus as compared to benzimidazole, 2-methylmenzimidazole and ampicillin. Compound P2 and P9 showed better antifungal activity against Candida albicans as compared to benzimidazole, 2-methylbenzimidazole and griseofulvin.
Polyethyleneglycol Catalysed N-Sulphonylation and N-Benzoylation of Substituted Benzimidazoles
Kumar, P. Raja
, p. 1273 - 1274 (2007/10/02)
Benzenesulphonyl chloride and p-toluenesulphonyl chloride react with benzimidazole and 2-phenylbenzimidazole in benzene and 50percent aqueous sodium hydroxide in the presence of polyethyleneglycol 400 or triethylbenzylammonium chloride to afford the corresponding N-sulphonyl derivatives.However, 2-methylbenzimidazole affords both N-sulphonylated and C-sulphonylated products.N-Benzoylation is also effected under similar conditions using benzoyl chloride.
