925922-24-3

Basic information

• Product Name: 2-amino-6-(2-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-4-(4-nitrophenyl)nicotinonitrile
• Synonyms: 2-amino-6-(2-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-4-(4-nitrophenyl)nicotinonitrile
• CAS NO: 925922-24-3
• Molecular Weight: 446.581
• Mol File: 925922-24-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-amino-6-(2-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-4-(4-nitrophenyl)nicotinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-6-(2-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-4-(4-nitrophenyl)nicotinonitrile(925922-24-3)
• EPA Substance Registry System: 2-amino-6-(2-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-4-(4-nitrophenyl)nicotinonitrile(925922-24-3)

Safety Data

• Hazardous Substances Data: 925922-24-3(Hazardous Substances Data)

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 120820-40-8 1-(2-(((1,1-dimethylethyl)dimethylsilyl)oxy)phenyl)ethanone 
• 109-77-3 malononitrile 

Downstream Products

• 925922-26-5 N-[6-(2-[tert-butyl(dimethyl)silyloxy]phenyl)-3-cyano-4-(4-nitrophenyl)pyridin-2-yl]thiophene-2-carboxamide 

Relevant articles and documents

PYRIDYLPHENOL COMPOUND AND USE THEREOF

The present invention provides a compound which has metastin receptor antagonist activity and is useful for preventing and treating hormone-dependent cancer, benign prostatomegaly, endometriosis, precocious puberty, uterine myoma or the like. More specifically, the present invention provides a compound, represented by the formula: or a salt thereof, a prodrug thereof, and a pharmaceutical agent containing the same; wherein Ring A represents a 5- to 8-membered homocyclic or heterocyclic group optionally having a substituent other than formula -X-R1 wherein X represents a bond or a spacer, and R1 represents optionally substituted amino or an optionally substituted nitrogen-containing heterocyclic group; Ring B represents an optionally substituted benzene ring; R2 represents an optionally substituted homocyclic or heterocyclic group; and R3 and R4 independently represent a hydrogen atom, cyano, acyl or an optionally substituted hydrocarbon group.