92641-15-1Relevant articles and documents
Production of 1-phthalidyl-5-fluorouracil derivatives
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, (2008/06/13)
Highly selective and high yield process for producing antitumor agent 1-phthalidyl-5-fluorouracil derivatives of formula (I) which comprises reacting a phthalidyl compound (II) with an amine (III) to yield the quaternary ammonium salts (IV), and reacting the latter with 5-fluorouracil. STR1 [wherein X is leaving group; STR2 is triethylamine, N-methylmorpholine, N-ethylmorpholine, and the like; R4 and R5 each is hydrogen, trialkylsilyloxy, alkoxy, nitro, cyano, carboxy, or alkoxycarbonyl].