92684-01-0Relevant articles and documents
Organic Syntheses Based on 2-Oxoglutaric Acid. II. On the Synthesis of Heterocycles by Reactions of Dimethyl 3-bromo-2-oxoglutarate with Binucleophiles
Hartenstein, H.,Blitzke, T.,Sicker, D.,Wilde, H.
, p. 176 - 180 (1993)
Reactions of dimethyl 3-bromo-2-oxoglutarate 2 with binucleophiles to form heterocycles proceed on two different pathways depending on the type of reactant.Thus, strong S-nucleophiles like thioureas and thiocarbohydrazide substitute initially the bromine atom and form 2-aminothiazoles 3 - 7 and the 1,3,4-thiadiazine 8.However, o-phenylendiamines reacted to form the brominated quinoxaline-2(1H)-one derivatives 9 and 10, resp.