926907-37-1Relevant articles and documents
Identification of isothiazole-4-carboxamidines derivatives as a novel class of allosteric MEK1 inhibitors
El Abdellaoui, Hassan,Varaprasad, Chamakura V.N.S.,Barawkar, Dinesh,Chakravarty, Subrata,Maderna, Andreas,Tam, Robert,Chen, Huanming,Allan, Matt,Wu, Jim Z.,Appleby, Todd,Yan, Shunqi,Zhang, Weijian,Lang, Stanley,Yao, Nanhua,Hamatake, Robert,Hong, Zhi
, p. 5561 - 5566 (2006)
The development of potent, orally bioavailable, and selective series of 5-amino-3-hydroxy-N(1-hydroxypropane-2-yl)isothiazole-4-carboxamidine inhibitors of MEK1 and MEK-2 kinase is described. Optimization of the carboxamidine and the phenoxyaniline group
