926922-37-4

Basic information

• Product Name: 1-BOC-4-BROMO-1H-INDAZOLE
• Synonyms: 1-BOC-4-BROMO-1H-INDAZOLE;tert-butyl 4-bromo-1H-indazole-1-carboxylate;4-Bromo-1H-indazole, N1-BOC protected;1H-INDAZOLE-1-CARBOXYLIC ACID,4-BROMO-,1,1-DIMETHYLETHYL ESTER;4-Bromo-1H-indazole-1-carboxylic acid tert-butyl ester;4-Bromoindazole-1-carboxylic acid tert-butyl ester;tert-butyl 4-bromoindazole-1-carboxylate
• CAS NO: 926922-37-4
• Molecular Formula: C₁₂H₁₃BrN₂O₂
• Molecular Weight: 297.16
• Mol File: 926922-37-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-BOC-4-BROMO-1H-INDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BOC-4-BROMO-1H-INDAZOLE(926922-37-4)
• EPA Substance Registry System: 1-BOC-4-BROMO-1H-INDAZOLE(926922-37-4)

Safety Data

• Hazardous Substances Data: 926922-37-4(Hazardous Substances Data)

Usage

General Description

1-BOC-4-BROMO-1H-INDAZOLE, also known as tert-butoxycarbonyl-4-bromo-1H-indazole, is a chemical compound with the molecular formula C11H11BrN2O2. It is a brominated indazole derivative with a tert-butoxycarbonyl (BOC) protective group attached to the nitrogen atom. 1-BOC-4-BROMO-1H-INDAZOLE has potential applications in organic synthesis and medicinal chemistry, particularly in the development of pharmaceuticals. It is often used as an intermediate in the synthesis of various biologically active molecules and pharmaceutical compounds. Additionally, its unique structure and reactivity make it a valuable building block for the development of new chemical entities in drug discovery research. The presence of the BOC protective group enhances the compound's stability and allows for controlled release of the active indazole moiety in specific chemical reactions.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 186407-74-9 4-bromoindazole 

Relevant articles and documents

Application of C-H Functionalization in the Development of a Concise and Convergent Route to the Phosphatidylinositol-3-kinase Delta Inhibitor Nemiralisib

This paper describes the development of an improved and scalable method for the manufacture of nemiralisib, a phosphatidylinositol-3-kinase delta inhibitor. Incorporation of three consecutive catalytic reactions, including a palladium-catalyzed C-H functionalization and an iridium-catalyzed borylation, significantly simplified and shortened the synthetic sequence. The revised route was successfully implemented in a pilot plant on a multikilogram scale to deliver >100 kg of product.

NOVEL COMPOUNDS

The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase L1 (UCHL1). The invention further relates to the use of DUB inhibitors in the treatment of cancer and other indications. Compounds of the invention include compounds having the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R8 are as defined herein.