927390-83-8

Basic information

• Product Name: 4-Benzoxazolecarbonitrile, 7-fluoro-5-methyl-2-(1-methyl-1H-pyrrol-2-yl)-6-phenyl-
• CAS NO: 927390-83-8
• Molecular Formula: C20H14FN3O
• Molecular Weight: 331.349
• Mol File: 927390-83-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-Benzoxazolecarbonitrile, 7-fluoro-5-methyl-2-(1-methyl-1H-pyrrol-2-yl)-6-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Benzoxazolecarbonitrile, 7-fluoro-5-methyl-2-(1-methyl-1H-pyrrol-2-yl)-6-phenyl-(927390-83-8)
• EPA Substance Registry System: 4-Benzoxazolecarbonitrile, 7-fluoro-5-methyl-2-(1-methyl-1H-pyrrol-2-yl)-6-phenyl-(927390-83-8)

Safety Data

• Hazardous Substances Data: 927390-83-8(Hazardous Substances Data)

Upstream product

• 98-80-6 phenylboronic acid 
• 927388-83-8 2-amino-4-fluoro-3-hydroxy-6-methyl-5-phenylbenzonitrile 
• 927389-30-8 2-amino-5-bromo-4-fluoro-3-hydroxy-6-methylbenzonitrile 
• 927390-34-9 2-chloro-7-fluoro-5-methyl-6-phenyl-1,3-benzoxazole-4-carbonitrile 
• 118486-97-8 1-methyl-2-(tributyltin)pyrrole 

Relevant articles and documents

Structure-activity relationships of 1,3-benzoxazole-4-carbonitriles as novel antifungal agents with potent in vivo efficacy

A series of 1,3-benzoxazole-4-carbonitriles was synthesized and evaluated for its antifungal activity, solubility, and metabolic stability. Among those compounds, 4-cyano-N,N,5-trimethyl-7-[(3S)-3-methyl-3-(methylamino) pyrrolidin-1-yl]-6-phenyl-1,3-benzoxazole-2-carboxamide (16b) exhibited potent in vitro activity against Candida species, higher water solubility, and improved metabolic stability compared to lead compound 1. Compound 16b showed potent in vivo efficacy against mice Candida infection models and good bioavailability in rats.