92760-72-0

Basic information

• Product Name: (S)-2-AMINO-2-METHYL-BUTYRIC ACID METHYL ESTER HYDROCHLORIDE
• Synonyms: METHYL D-ISOVALINE HYDROCHLORIDE;(S)-2-AMINO-2-METHYL-BUTYRIC ACID METHYL ESTER HYDROCHLORIDE;L-Isovaline, methyl ester, hydrochloride (1:1);Methyl D-isovaline HCl
• CAS NO: 92760-72-0
• Molecular Formula: C₆H₁₃NO₂*ClH
• Molecular Weight: 167.63
• Mol File: 92760-72-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 191.4 °C at 760 mmHg
• Flash Point: 69.5 °C
• Appearance: /
• Vapor Pressure: 0.438mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: (S)-2-AMINO-2-METHYL-BUTYRIC ACID METHYL ESTER HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-AMINO-2-METHYL-BUTYRIC ACID METHYL ESTER HYDROCHLORIDE(92760-72-0)
• EPA Substance Registry System: (S)-2-AMINO-2-METHYL-BUTYRIC ACID METHYL ESTER HYDROCHLORIDE(92760-72-0)

Safety Data

• Hazardous Substances Data: 92760-72-0(Hazardous Substances Data)

Usage

General Description

(S)-2-AMINO-2-METHYL-BUTYRIC ACID METHYL ESTER HYDROCHLORIDE, also known as L-Tert-Leucine methyl ester hydrochloride, is a chemical compound with the molecular formula C6H13NO2·HCl. It is a derivative of the amino acid leucine, and is commonly used in the synthesis of pharmaceuticals and other organic compounds. (S)-2-AMINO-2-METHYL-BUTYRIC ACID METHYL ESTER HYDROCHLORIDE is a white crystalline solid with a melting point of around 174-178°C. It is also known to exhibit antifungal and antitumor activities and is used as a chiral auxiliary in asymmetric synthesis. Additionally, (S)-2-AMINO-2-METHYL-BUTYRIC ACID METHYL ESTER HYDROCHLORIDE is used in the preparation of peptide drugs and is a valuable building block in organic synthesis.

InChI:InChI=1/C6H13NO2.ClH/c1-4-6(2,7)5(8)9-3;/h4,7H2,1-3H3;1H/t6-;/m0./s1

Upstream product

• 67-56-1 methanol 
• 43177-22-6 (2S)-2-amino-2-methylbutanoic acid hydrochloride 
• 595-40-4 L-isovaline 
• 118995-18-9 (2R,4S)-3-Benzoyl-4-ethyl-4-methyl-2-phenyl-oxazolidin-5-one 

Downstream Products

• 328402-29-5 Z-L-Iva-L-ATANP(Boc)2-(L-Iva)2-OMe 
• 171416-15-2 Boc-Gly-L-Iva-L-Pro-OBzl 
• 1025817-73-5 (S)-1-[(S)-2-(2-Amino-acetylamino)-2-methyl-butyryl]-pyrrolidine-2-carboxylic acid [(4-nitro-phenylcarbamoyl)-methyl]-amide 
• 171416-08-3 Boc-Gly-L-Iva-L-Pro-Gly-pNA 
• 171416-17-4 Boc-Gly-L-Iva-L-Pro-Gca-pNA 
• 160171-18-6 (+)-S-zoxamide 

Relevant articles and documents

Enantiomer mixture and preparation method and application thereof

The invention provides an enantiomer mixture and a preparation method and application thereof, and belongs to the technical field of pesticide chemistry and organic synthesis. The enantiomer mixture is a mixture of S-zoxamide and R-zoxamide, and the enant

The first water-soluble 310-helical peptides

Two water-soluble 310-helical peptides are synthesized and fully characterized for the first time. The sequence of these terminally blocked heptamers comprises two residues of the Cα-trisubstituted α-amino acid 2-amino-3-[1-(1,4,7 triazacyclononyl)]propanoic acid and five residues of a Cα-tetrasubstituted α-amino acid (either α-aminoisobutyric acid or isovaline). Using CD and NMR techniques we were able to show that both heptapeptides are well structured in water, and that the type of conformation adopted is indeed the ternary 310-helix.

Stereoselective synthesis of isovaline (IVA) and IVA-containing dipeptides for use in peptide synthesis

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