928006-46-6

Basic information

• Product Name: {2-[methyl-(5-pyrrolidin-1-yl-pentyl)-amino]-3-phenyl-3,4-dihydro-quinazolin-4-yl}-acetic acid
• Synonyms: {2-[methyl-(5-pyrrolidin-1-yl-pentyl)-amino]-3-phenyl-3,4-dihydro-quinazolin-4-yl}-acetic acid
• CAS NO: 928006-46-6
• Molecular Weight: 434.582
• Mol File: 928006-46-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: {2-[methyl-(5-pyrrolidin-1-yl-pentyl)-amino]-3-phenyl-3,4-dihydro-quinazolin-4-yl}-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: {2-[methyl-(5-pyrrolidin-1-yl-pentyl)-amino]-3-phenyl-3,4-dihydro-quinazolin-4-yl}-acetic acid(928006-46-6)
• EPA Substance Registry System: {2-[methyl-(5-pyrrolidin-1-yl-pentyl)-amino]-3-phenyl-3,4-dihydro-quinazolin-4-yl}-acetic acid(928006-46-6)

Safety Data

• Hazardous Substances Data: 928006-46-6(Hazardous Substances Data)

Upstream product

• 954-81-4 N-(5-bromopentyl)phthalimide 
• 111-24-0 1,5-dibromo-pentane 
• 928006-41-1 2-(5-(pyrrolidin-1-yl)pentyl)isoindoline-1,3-dione 
• 928006-42-2 t-butyl (5-pyrrolidin-1-ylpentyl)carbamate 
• 928006-43-3 N-methyl-5-(pyrrolidin-1-yl)pentan-1-amine 
• 71302-71-1 5-(pyrrolidin-1-yl)pentan-1-amine 
• 928006-44-4 KYS₀₅₀₇₆ 

Relevant articles and documents

Synthesis and SAR study of T-type calcium channel blockers. Part II

3,4-Dihydroquinazoline derivatives have been known to be the novel and potent T-type calcium channel blockers. From a systematic variation of 3,4-dihydroquinazoline derivative 5c (KYS05043), plausible SAR results were established. It was revealed that a 5-(dimethylamino)pentylamino group at R 1, a biphenyl group at R2, and a benzyl amido group at R3 in the 3,4-dihydroquinazoline backbone are closely related with the channel selectivity (T/N-type) as well as the potency based on the discovery of 6k (KYS05090).