92814-42-1

Basic information

• Product Name: (R)-6-amino-1,4-thiazepan-5-one
• Synonyms: (R)-6-amino-1,4-thiazepan-5-one;1,4-Thiazepin-5(2H)-one,6-aminotetrahydro-,(6R)-(9CI);(6R)-6-aMino-1,4-thiazepan-5-one;(R)-6-Amino-1,4-thiazepan-5-one hydrochloride
• CAS NO: 92814-42-1
• Molecular Formula: C₅H₁₀N₂OS
• Molecular Weight: 146.2107
• Product Categories: AMINEPRIMARY
• Mol File: 92814-42-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 389.7 °C at 760 mmHg
• Flash Point: 189.5 °C
• Appearance: /
• Density: 1.181 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.53
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: (R)-6-amino-1,4-thiazepan-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-6-amino-1,4-thiazepan-5-one(92814-42-1)
• EPA Substance Registry System: (R)-6-amino-1,4-thiazepan-5-one(92814-42-1)

Safety Data

• Hazardous Substances Data: 92814-42-1(Hazardous Substances Data)

Usage

General Description

(R)-6-amino-1,4-thiazepan-5-one is a chemical compound with the molecular formula C5H10N2OS. It is a heterocyclic organic compound that contains a thiazepane ring with an amino group at the 6th carbon and a carbonyl group at the 5th carbon. (R)-6-amino-1,4-thiazepan-5-one has potential pharmaceutical applications, particularly in the development of novel drugs for neurological and psychiatric disorders. It is also being researched for its potential use in treating mood disorders and anxiety. Additionally, (R)-6-amino-1,4-thiazepan-5-one has been investigated for its anti-inflammatory and immunomodulatory properties, making it a potentially important compound for the development of new therapies for various medical conditions.

InChI:InChI=1/C5H10N2OS/c6-4-3-9-2-1-7-5(4)8/h4H,1-3,6H2,(H,7,8)

Upstream product

• 870-24-6 2-chloroethanamine hydrochloride 
• 18598-63-5 L-cysteine methyl ester hydrochloride 
• 2485-62-3 L-Cysteine methyl ester 

Downstream Products

• 256656-62-9 [(S)-2-[4-(Bis-benzyloxy-phosphoryloxy)-phenyl]-1-((R)-5-oxo-[1,4]thiazepan-6-ylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester 
• 635706-27-3 ((R)-6-benzoylamino-5-oxo-[1,4]thiazepa-4-yl)-acetic acid 
• 635706-26-2 ((R)-6-benzoylamino-5-oxo-[1,4]thiazepa-4-yl)-acetic acid ethyl ester 
• 911304-65-9 [(R)-5-Oxo-6-(3-trifluoromethyl-benzoylamino)-[1,4]thiazepan-4-yl]-acetic acid 
• 911304-61-5 [(R)-5-Oxo-6-(3-trifluoromethyl-benzoylamino)-[1,4]thiazepan-4-yl]-acetic acid ethyl ester 
• 635706-28-4 N-{(R)-4-[((S)-2-ethoxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-methyl]-5-oxo-1-[1,4]thiazepan-6-yl}-benzamide 
• 635706-30-8 N-{(R)-4-[((S)-2-ethoxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-methyI]-1,1,5-trioxo-1λ6-[1,4]thiazepan-6-yl}-benzamide 
• 911304-49-9 N-{(R)-4-[((S)-2-Ethoxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-methyl]-5-oxo-[1,4]thiazepan-6-yl}-3-trifluoromethyl-benzamide 
• 911304-55-7 N-{(R)-4-[((S)-2-Ethoxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-methyl]-1,1,5-trioxo-1λ⁶-[1,4]thiazepan-6-yl}-3-trifluoromethyl-benzamide 
• 256656-63-0 {(S)-2-[4-(Bis-benzyloxy-phosphoryloxy)-phenyl]-1-[(R)-4-(3-cyclohexyl-propyl)-5-oxo-[1,4]thiazepan-6-ylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester 

Relevant articles and documents

Synthesis and evaluation of thiazepines as interleukin-1β converting enzyme (ICE) inhibitors

A series of monocyclic thiazepine inhibitors of interleukin-1β converting enzyme (ICE) were synthesized in eight steps from commercially available intermediates. In vitro biological evaluation showed the thiazepines to be moderately potent ICE inhibitors,

DERIVATIVES OF AZEPINE AND THIAZERAN AS INTERLEUKIN CONVERTING ENZYME INHIBITORS

The present invention relates to interleukin - Iβ converting enzyme inhibitors of formula I: wherein each X is independently selected from: i) -C(W)2-; ii) -C(O)-; iii) -NR2-; iv) -S-; v) -S(O)-; vi) -S(O)2-; vii) two units, one from each adjacent X unit,