928209-81-8Relevant articles and documents
Stereogenic evolution of clasto-lactacystin β-lactone from L-serine
Yoon, Cheol H.,Flanigan, David L.,Yoo, Kyung S.,Jung, Kyung W.
, p. 37 - 39 (2007/10/03)
Reported herein is a novel synthesis of clasto-lactacystin β-lactone. The γ-lactam core was selectively prepared by an intramolecular C-H insertion to establish the stereocenter, C(6). The ensuing construction of the quaternary C(5) and carbinol C(9) cent