92828-40-5Relevant articles and documents
Synthesis of the GPR40 partial agonist MK-8666 through a kinetically controlled dynamic enzymatic ketone reduction
Hyde, Alan M.,Liu, Zhijian,Kosjek, Birgit,Tan, Lushi,Klapars, Artis,Ashley, Eric R.,Zhong, Yong-Li,Alvizo, Oscar,Agard, Nicholas J.,Liu, Guiquan,Gu, Xiuyan,Yasuda, Nobuyoshi,Limanto, John,Huffman, Mark A.,Tschaen, David M.
supporting information, p. 5888 - 5891 (2016/11/29)
A scalable and efficient synthesis of the GPR40 agonist MK-8666 was developed from a simple pyridine building block. The key step to set the stereochemistry at two centers relied on an enzymatic dynamic kinetic reduction of an unactivated ketone. Directed
HIGHLY STEREOSELECTIVE RADICAL ADDITION TO A TRISUBSTITUTED ALKENE BY LOW TEMPERATURE PHOTOLYSIS OF THIOHYDROXAMIC ESTERS
Scott, Daniel M.,McPhail, Andrew T.,Porter, Ned A.
, p. 1679 - 1682 (2007/10/02)
Low temperature carbon radical addition to α,β-unsaturated amides of trans-2,5-dimethylpyrrolidine was achieved in high yield with high diastereoselectivity by photolysis of Barton esters.Use of an olefin substituted with three electron withdrawing groups