92829-67-9Relevant articles and documents
Synthesis of Functionalized 2-(4-Hydroxyphenyl)-3-methylbenzofuran Allosteric Modulators of Hsp90 Activity
Sattin, Sara,Panza, Matteo,Vasile, Francesca,Berni, Francesca,Goti, Giulio,Tao, Jiahui,Moroni, Elisabetta,Agard, David,Colombo, Giorgio,Bernardi, Anna
supporting information, p. 3349 - 3364 (2016/07/26)
Hsp90 is a molecular chaperone that plays a pivotal role in the cell life cycle. ATP-regulated internal dynamics are critical to Hsp90 function and we recently demonstrated that these dynamics can be modulated in an allosteric fashion; the protein C-terminal domain (CTD) can be effectively targeted with a family of 2-phenyl-benzofuran derivatives. Here we describe the expansion of the initial library, reporting 28 new derivatives that explore the chemical space at opposite ends of the benzofuran scaffold. Interactions of the compounds with a full-length protein homolog were explored by Saturation Transfer Difference (STD) NMR spectroscopy. In this context we also report the interaction epitope of Novobiocin, a known CTD inhibitor.
Selective Ligands for the Neuronal Nicotinic Receptors and Uses Thereof
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Page/Page column 27, (2009/12/04)
The present application describes selective ligands of formula (I) for neuronal nicotinic receptors (NNRs), more specifically for the α4β2 NNR subtype, compositions thereof, and methods of using the same, wherein X, R1, X, R2, R3, L1, m, n, p, and q are defined in the specification.
Control of parasites in animals by the use of novel trifluoromethanesulfonanilide oxime ether derivatives
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Page/Page column 28, (2010/10/20)
Novel trifluoromethanesulfonanilide oxime ether compounds useful for controlling endo and/or ectoparasites in the environment are provided, together with methods of making the same, and methods of using the inventive compounds to treat parasite infestations in vivo or ex vivo.