92829-83-9Relevant articles and documents
EMULSION WITH IMPROVED BIOABSORPTION COMPOSITION COMPRISING CATIONIC POLYESTER COPOLYMER AND HYDROPHOBIC DRUG AND METHOD FOR PREPARING THE SAME
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Paragraph 0122; 0126, (2019/01/12)
The present invention relates to an emulsion composition with an improved bioabsorption rate containing a cationic polyester-based copolymer, and a poorly soluble drug. The emulsion composition comprises: a cationic polyester-based copolymer including a c
COMPOUNDS USEFUL AS KINASE INHIBITORS
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Paragraph 00288, (2017/07/14)
This invention relates to novel compounds. The compounds of the invention are tyrosine kinase inhibitors. Specifically, the compounds of the invention are useful as inhibitors of Bruton's tyrosine kinase (BTK).The invention also contemplates the use of the compounds for treating conditions treatable by the inhibition of Bruton's tyrosine kinase, for example cancer, lymphoma, leukemia and immunological diseases.
Stereoelectronic Model to Explain Highly Stereoselective Reactions of Seven-Membered-Ring Oxocarbenium-Ion Intermediates
Beaver, Matthew G.,Buscagan, Trixia M.,Lavinda, Olga,Woerpel
supporting information, p. 1816 - 1819 (2016/02/03)
Nucleophilic attack on seven-membered-ring oxocarbenium ions is generally highly stereoselective. The preferred mode of nucleophilic attack forms the product in a conformation that minimizes transannular interactions, thus leading to different stereoselectivity as compared to that of reactions involving six-membered-ring oxocarbenium ions.