92832-02-5

Basic information

• Product Name: Phenol, 4-bromo-2-(1-iminoethyl)-
• CAS NO: 92832-02-5
• Molecular Formula: C8H8BrNO
• Molecular Weight: 214.062
• Mol File: 92832-02-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Phenol, 4-bromo-2-(1-iminoethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 4-bromo-2-(1-iminoethyl)-(92832-02-5)
• EPA Substance Registry System: Phenol, 4-bromo-2-(1-iminoethyl)-(92832-02-5)

Safety Data

• Hazardous Substances Data: 92832-02-5(Hazardous Substances Data)

Upstream product

• 1450-75-5 5-Bromo-2-hydroxyacetophenone 

Downstream Products

• 1228571-89-8 (S)-2-(1-aminoethyl)-4-bromophenol 
• 741625-48-9 2-(1-aminoethyl)-4-bromophenol 
• 66033-76-9 5-bromo-3-methyl-1,2-benzisoxazole 
• 1314136-00-9 3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzisoxazole 

Relevant articles and documents

One-Pot Synthesis of Diazirines and 15N2-Diazirines from Ketones, Aldehydes and Derivatives: Development and Mechanistic Insight

Broad scope one-pot diazirine synthesis strategies have been developed using two different oxidants depending on the nature of the starting material. In all cases, an inexpensive commercial solution of ammonia (NH3) in methanol (MeOH) was emplo

Derisking the Cu-Mediated 18F-Fluorination of Heterocyclic Positron Emission Tomography Radioligands

Molecules labeled with fluorine-18 (18F) are used in positron emission tomography to visualize, characterize and measure biological processes in the body. Despite recent advances in the incorporation of 18F onto arenes, the development of general and efficient approaches to label radioligands necessary for drug discovery programs remains a significant task. This full account describes a derisking approach toward the radiosynthesis of heterocyclic positron emission tomography (PET) radioligands using the copper-mediated 18F-fluorination of aryl boron reagents with 18F-fluoride as a model reaction. This approach is based on a study examining how the presence of heterocycles commonly used in drug development affects the efficiency of 18F-fluorination for a representative aryl boron reagent, and on the labeling of more than 50 (hetero)aryl boronic esters. This set of data allows for the application of this derisking strategy to the successful radiosynthesis of seven structurally complex pharmaceutically relevant heterocycle-containing molecules.

Chiral phosphoric acid-catalyzed enantioselective transfer hydrogenation of ortho-hydroxyaryl alkyl N - H ketimines

The first enantioselective chiral phosphoric acid-catalyzed transfer hydrogenation of unprotected ortho-hydroxyaryl alkyl N - H ketimines using Hantszch di-tert-butyl ester as a reductant is reported. A variety of ortho-hydroxybenzylamines were obtained in good to excellent yields and enantiomeric excesses.