928664-14-6

Basic information

• Product Name: 4-fluoroisoquinolin-5-amine
• Synonyms: 5-Isoquinolinamine, 4-fluoro-
• CAS NO: 928664-14-6
• Molecular Formula: C₉H₇FN₂
• Molecular Weight: 162.1636832
• Mol File: 928664-14-6.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-fluoroisoquinolin-5-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-fluoroisoquinolin-5-amine(928664-14-6)
• EPA Substance Registry System: 4-fluoroisoquinolin-5-amine(928664-14-6)

Safety Data

• Hazardous Substances Data: 928664-14-6(Hazardous Substances Data)

Usage

General Description

4-fluoroisoquinolin-5-amine is a chemical compound with the molecular formula C9H7FN2. It is a derivative of isoquinoline with a fluorine atom attached to the fourth position of the aromatic ring. 4-fluoroisoquinolin-5-amine has potential applications in the field of organic synthesis and pharmaceutical research. Its unique structure and properties make it a valuable intermediate for the development of new drugs and other bioactive compounds. Additionally, its fluorinated structure makes it an interesting target for further studies in medicinal chemistry and drug discovery.

Upstream product

• 928664-13-5 4-fluoro-5-nitroisoquinoline 
• 1532-97-4 4-bromoisoquinoline 
• 394-67-2 4--fluoroisoquinoline 
• 491-30-5 1-hydroxyisoquinoline 

Downstream Products

• 194032-33-2 4-fluoro-5-isoquinolinesulfonyl chloride 

Relevant articles and documents

ROCK KINASE INHIBITORS

The present invention relates to compounds that inhibit ROCK activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of inhibiting ROCK activity and methods for treating, for example cerebral cavernous malformation syndrome (CCM) and cardiovascular diseases using the compounds and pharmaceutical compositions of the present invention.

ISOQUINOLINESULFONYL DERIVATIVE AS RHO KINASE INHIBITOR

The present invention discloses a class of isoquinolinesulfonyl derivatives as RHO kinase inhibitors, and pharmaceutical compositions thereof, and relates to pharmaceutically acceptable uses thereof. Specifically, the present invention relates to a compound as represented by formula (I), or a pharmaceutically acceptable salt thereof.

Sulfonamide compound

A compound represented by the formula (1) [A represents a nitrogen-containing saturated ring; m represents an integer of 0 to 2; n represents an integer of 1 to 4; G1 represents hydrogen atom, chlorine atom, hydroxyl group, an alkoxy group, or amino group; G2 represents a halogen atom, hydroxyl group, cyano group, carboxy group, an alkyl group, an alkenyl group, an alkynyl group, an alkoxy group, an alkylthio group, an amino group, an alkylsulfinyl group, an alkylsulfonyl group, or an aryl group; G3 represents hydrogen atom, a halogen atom, hydroxyl group, cyano group, carboxy group, an alkyl group, an alkenyl group, an alkynyl group, an alkoxy group, an alkylthio group, an amino group, an alkoxycarbonyl group, an acyl group, an acyloxy group, an alkylsulfinyl group, an alkylsulfonyl group, or an aryl group; Y represents a single bond, or —C(R3)(R4)— (R3 and R4 represent hydrogen atom, or an alkyl group, or alkylene groups which combine together to form a saturated hydrocarbon ring group); G4 represents hydroxyl group (Y is a single group), or —N(R1)(R2) (R1 and R2 represent hydrogen atom, an alkyl group, an aralkyl group, an alkenyl group, an alkynyl group, a saturated heterocyclic group, an alkylsulfonyl group, an acyl group, or an amidino group); G5 is a substituent on a ring-constituting carbon atom of A, and represents hydrogen atom, fluorine atom, or an alkyl group] or a salt thereof, or a derivative thereof that is a prodrug, which potently inhibits Rho kinase.