92867-97-5

Basic information

• Product Name: phenyl(1-phenyl-1H-pyrazol-5-yl)methanone
• Synonyms: phenyl(1-phenyl-1H-pyrazol-5-yl)methanone
• CAS NO: 92867-97-5
• Molecular Weight: 248.284
• Mol File: 92867-97-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: phenyl(1-phenyl-1H-pyrazol-5-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: phenyl(1-phenyl-1H-pyrazol-5-yl)methanone(92867-97-5)
• EPA Substance Registry System: phenyl(1-phenyl-1H-pyrazol-5-yl)methanone(92867-97-5)

Safety Data

• Hazardous Substances Data: 92867-97-5(Hazardous Substances Data)

Upstream product

• 423768-37-0 1-phenyl-1H-pyrazole-5-carbonyl chloride 
• 1126-00-7 1-phenylpyrazole 
• 93-97-0 benzoic acid anhydride 
• 98-88-4 benzoyl chloride 

Relevant articles and documents

Design, synthesis, and evaluation of indeno[2,1-c]pyrazolones for use as inhibitors against hypoxia-inducible factor (HIF)-1 transcriptional activity

HIF-1 is regarded as a promising target for the drugs used in cancer chemotherapy, and creating readily accessible templates for the development of synthetic drug candidates that could inhibit HIF-1 transcriptional activity is an important pursuit. In this study, indeno[2,1-c]pyrazolones were designed as readily available synthetic inhibitors of HIF-1 transcriptional activity. Nine compounds were synthesized in 4–5 steps from commercially available starting materials. In evaluations of the ability to inhibit the hypoxia-induced transcriptional activity of HIF-1, compound 3c showed a higher level compared with that of known inhibitor, YC-1. The compound 3c suppressed HIF-1α protein accumulation without affecting the levels of HIF-1α mRNA.