928675-01-8

Basic information

• Product Name: (S)-4-[3-(trifluoromethyl)phenethyl]-1-[6-(aminomethyl)-1,2,3,4-tetrahydronaphthalen-2-yl]piperazin-2-one
• Synonyms: (S)-4-[3-(trifluoromethyl)phenethyl]-1-[6-(aminomethyl)-1,2,3,4-tetrahydronaphthalen-2-yl]piperazin-2-one
• CAS NO: 928675-01-8
• Molecular Weight: 431.501
• Mol File: 928675-01-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-4-[3-(trifluoromethyl)phenethyl]-1-[6-(aminomethyl)-1,2,3,4-tetrahydronaphthalen-2-yl]piperazin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4-[3-(trifluoromethyl)phenethyl]-1-[6-(aminomethyl)-1,2,3,4-tetrahydronaphthalen-2-yl]piperazin-2-one(928675-01-8)
• EPA Substance Registry System: (S)-4-[3-(trifluoromethyl)phenethyl]-1-[6-(aminomethyl)-1,2,3,4-tetrahydronaphthalen-2-yl]piperazin-2-one(928675-01-8)

Safety Data

• Hazardous Substances Data: 928675-01-8(Hazardous Substances Data)

Upstream product

• 928675-00-7 (S)-6-{4-[3-(trifluoromethyl)phenethyl]-2-oxopiperazin-1-yl}-5,6,7,8-tetrahydronaphthalene-2-carbonitrile 
• 928674-99-1 (S)-6-[(2-chloroethyl)amino]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile 
• 928675-19-8 {(2-chloro-ethyl)-[2-(3-trifluoromethyl-phenyl)-ethyl]-amino}-acetic acid methyl ester 
• 52516-30-0 2-(3-trifluoromethylphenyl)ethylamine 

Relevant articles and documents

The efficacy and cardiac evaluation of aminomethyl tetrahydronaphthalene ketopiperazines: A novel class of potent MCH-R1 antagonists

The design, synthesis, and biological studies of a novel class of MCH-R1 antagonists based on an aminotetrahydronaphthalene ketopiperazine scaffold is described. Compounds within this class promoted significant body weight reduction in mouse diet induced obesity studies. The potential for hERG blockage activity and QT interval studies in anesthetized dogs are discussed.