92897-32-0

Basic information

• Product Name: 6,7-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidin-3(2H)-one
• Synonyms: 5H-Thiazolo[3,2-a]pyrimidin-3(2H)-one, 6,7-dihydro-; 5H-Thiazolo[3,2-a]pyrimidin-3-one, 6,7-dihydro-; 6,7-Dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidin-3(2H)-one
• CAS NO: 92897-32-0
• Molecular Formula: C₆H₈N₂OS
• Molecular Weight: 156.2055
• Mol File: 92897-32-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 259.4°C at 760 mmHg
• Flash Point: 110.7°C
• Density: 1.57g/cm³
• Vapor Pressure: 0.013mmHg at 25°C
• Refractive Index: 1.758
• CAS DataBase Reference: 6,7-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidin-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidin-3(2H)-one(92897-32-0)
• EPA Substance Registry System: 6,7-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidin-3(2H)-one(92897-32-0)

Safety Data

• Hazardous Substances Data: 92897-32-0(Hazardous Substances Data)

Upstream product

• 2055-46-1 3,4,5,6-tetrahydropyrimidine-2-thione 
• 105-39-5 chloroacetic acid ethyl ester 
• 1703-23-7 N,N'-bis(chloroacetyl)piperazine 
• 42951-91-7 2-chloro-1-(4-methylpiperazin-1-yl)ethan-1-one hydrochloride 
• 93378-52-0 1-methyl-4-(2-tetrahydropyrimidinylthioacetyl)piperazine dihydrochloride 
• 79-11-8 chloroacetic acid 
• 2055-46-1 2-mercapto-3,4,5,6-tetrahydropyrimidine 
• 79-08-3 bromoacetic acid 

Downstream Products

• 92897-33-1 6,7-dihydro-2-benzylidene-5H-thiazolo<3,2-a>pyrimidine-3(2H)-one 
• 92897-47-7 2-[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-6,7-dihydro-5H-thiazolo[3,2-a]pyrimidin-3-one 

Relevant articles and documents

Heterocyclic substituted styrene compound and use thereof

The invention relates to a heterocyclic substituted styrene compound and its use. The invention discloses a heterocyclic radical, alkoxy and halogen modified styrene compound. Results of inhibition activity of the compound against Syk (spleen tyrosine kinase) show that the compound has inhibition activity against the Syk (spleen tyrosine kinase), and part of the compound has stronger inhibition activity against the Syk, and a structure foundation for further design and development of new Syk inhibitor-class rheumatoid arthritis (RA) therapy drugs is laid.

Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3- alkyl-2-(alkylimino)thiazolidin-4-one chemotype

High affinity and selective S1P4 receptor (S1P4-R) small molecule agonists may be important proof-of-principle tools used to clarify the receptor biological function and effects to assess the therapeutic potential of the S1P4-R in diverse disease areas including treatment of viral infections and thrombocytopenia. A high-throughput screening campaign of the Molecular Libraries-Small Molecule Repository was carried out by our laboratories and identified (2Z,5Z)-5-((1-(2-fluorophenyl)-2,5-dimethyl-1H- pyrrol-3-yl)methylene)-3-methyl-2-(methylimino) thiazolidin-4-one as a promising S1P4-R agonist hit distinct from literature S1P4-R modulators. Rational chemical modifications of the hit allowed the identification of a promising lead molecule with low nanomolar S1P4-R agonist activity and exquisite selectivity over the other S1P 1-3,5-Rs family members. The lead molecule herein disclosed constitutes a valuable pharmacological tool to explore the effects of the S1P4-R signaling cascade and elucidate the molecular basis of the receptor function.

Studies on thiazolidinones. Part-XII: Synthesis and antimicrobial activities of thiazolidinones and their derivatives from cyclic thioureas

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