92902-76-6

Basic information

• Product Name: bis-(2-chloro ethyl)-(3-methoxy-benzyl)-amine
• Synonyms: bis-(2-chloro ethyl)-(3-methoxy-benzyl)-amine
• CAS NO: 92902-76-6
• Molecular Weight: 262.179
• Mol File: 92902-76-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: bis-(2-chloro ethyl)-(3-methoxy-benzyl)-amine(CAS DataBase Reference)
• NIST Chemistry Reference: bis-(2-chloro ethyl)-(3-methoxy-benzyl)-amine(92902-76-6)
• EPA Substance Registry System: bis-(2-chloro ethyl)-(3-methoxy-benzyl)-amine(92902-76-6)

Safety Data

• Hazardous Substances Data: 92902-76-6(Hazardous Substances Data)

Upstream product

• 111-42-2 2,2'-iminobis[ethanol] 
• 824-98-6 m-methoxybenzyl chloride 
• 212770-56-4 2-[(2-hydroxy-ethyl)-(3-methoxy-benzyl)-amino]-ethanol 

Downstream Products

• 212770-58-6 4-(4-methoxy-benzenesulfonyl)-1-(3-methoxy-benzyl)-piperidine-4-carboxylic acid ethyl ester 

Relevant articles and documents

N-HYDROXY-2-(ALKYL, ARYL, OR HETEROARYL SULFANYL, SULFINYL OR SULFONYL)-3-SUBSTITUTED ALKYL, ARYL OR HETEROARYLAMIDES AS MATRIX METALLOPROTEINASE INHIBITORS

Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenases, stromelysins and gelatinases. TNF- alpha converting enzymes (TACE), a pro-inflammatory cytokine, catalyze the formation of TNF- alpha from membrane-bound TNF- alpha precursor protein. It is expected that small molecule inhibitors of MMPs and TACE therefore have the potential for treating a variety of disease states. The present invention provides low molecular weight, non-peptide inhibitors of matrix metalloproteinases (MMPs) and TNF- alpha converting enzyme (TACE) for the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection. The compounds of this invention are represented by formula (I), where R, R, R and R are described herein.