929048-08-8

Basic information

• Product Name: (2S)-[[[(PHENYLMETHOXY)CARBONYL]AMINO]METHYL]-1-PYRROLIDINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER
• Synonyms: (2S)-[[[(PHENYLMETHOXY)CARBONYL]AMINO]METHYL]-1-PYRROLIDINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER;(S)-(N-BOC-PYRROLIDIN-2-YL)-N-CBZ-METHANAMINE;(S)-2-[[(Benzyloxycarbonyl)amino]methyl]pyrrolidine-1-carboxylic acid tert-butyl ester
• CAS NO: 929048-08-8
• Molecular Formula: C₁₈H₂₆N₂O₄
• Molecular Weight: 334.41
• Mol File: 929048-08-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Density: 1.137
• CAS DataBase Reference: (2S)-[[[(PHENYLMETHOXY)CARBONYL]AMINO]METHYL]-1-PYRROLIDINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-[[[(PHENYLMETHOXY)CARBONYL]AMINO]METHYL]-1-PYRROLIDINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER(929048-08-8)
• EPA Substance Registry System: (2S)-[[[(PHENYLMETHOXY)CARBONYL]AMINO]METHYL]-1-PYRROLIDINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER(929048-08-8)

Safety Data

• Hazardous Substances Data: 929048-08-8(Hazardous Substances Data)

Usage

General Description

The chemical compound "(2S)-[[[(phenylmethoxy)carbonyl]amino]methyl]-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester" is a specific ester derivative of the amino acid proline. It is commonly used in pharmaceutical research and development, particularly in the synthesis of proline derivatives for potential drug candidates. (2S)-[[[(PHENYLMETHOXY)CARBONYL]AMINO]METHYL]-1-PYRROLIDINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER plays a crucial role in drug discovery, as proline derivatives have been found to possess various biological activities, including antiviral, anticancer, and anti-inflammatory properties. Its unique structure and properties make it a promising candidate for further investigation and potential drug development.

Upstream product

• 501-53-1 benzyl chloroformate 
• 119020-01-8 (S)-2-(aminomethyl)pyrrolidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 1217652-74-8 (S)-2-(benzyloxycarbonylaminomethyl)pyrrolidine hydrochloride 
• 913614-57-0 2-amino-3,5-dihydro-7-[[(2S)-2-(benzyloxycarbonylaminomethyl)-1-pyrrolidinyl]methyl]-4H-pyrrolo[3,2-d]pyrimidin-4-one 
• 913614-65-0 phenylmethyl [(2S)-2-pyrrolidinylmethyl]carbamate 

Relevant articles and documents

PYRIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PSYCHOTIC DISORDERS

There are provided according to the invention novel compounds of formula (I) or a pharmaceutically acceptable salt thereof: (I) wherein: X represents a nitrogen atom; Y represents -C(H2)-, (-C(H2)-)2, -S(O2)- or -C(=O)-; Z represents -C(H2)-, -S(O2)-, -N(Rz)-, or an oxygen or sulphur atom; A represents hydrogen or -CH2OH; Rz represents hydrogen, C1-6 alkyl, C1-6 alkoxy, -COR7 or -SO2R7; R1 represents halogen, C1-6 alkyl, C1-6 alkoxy, =O, haloC1-6 alkyl, haloC1-6 alkoxy, hydroxyl or -CH2OH; m represents an integer from 0 to 3; R2 represents halogen, =O, C1-6alkyl (optionally substituted by one or more hydroxyl groups), -COOR7, -CONR7R8, C1-6 alkoxy, haloC1-6 alkyl, haloC1-6alkoxy or C1-6 alkyloC1-6 alkyl; n represents an integer from 0 to 3; p and q independently represent an integer from 0 to 2; R3 represents an -aryl, -heteroaryl, -heterocyclyl, -aryl-aryl, -aryl-heteroaryl, -aryl-heterocyclyl, -heteroaryl-aryl, -heteroaryl-heteroaryl, -heteroaryl-heterocyclyl, -heterocyclyl-aryl, -heterocyclyl-heteroaryl or -heterocyclyl-heterocyclyl group, all of which may be optionally substituted by one or more (e.g. 1, 2 or 3) halogen, C1-6 alkyl (optionally substituted by one or more hydroxyl groups), C3-8cycloalkyl, C1-6 alkoxy, hydroxyl, haloC1-6alkyl, haloC1-6 alkoxy, cyano, -S-C1-6 alkyl, -SO-C1-6 alkyl, -SO2-C1-6 alkyl, -COR7, -CONR7R8, -NR7R8, -NR7COC1-6 alkyl, -NR7SO2-C1-6alkyl, C1-6 alkyl-NR7R8, -OCONR7R8 , -NR7CO2R8 or -SO2NR7R8 groups; R4 and R5 independently represent C1-6 alkyl, or R4 and R5 together with the carbon atom to which they are attached may together form a C3-8cycloalkyl group; R6 represents halogen, C1-6 alkyl, C3-8cycloalkyl, C1-6 alkoxy, haloC1-6 alkyl or haloC1-6 alkoxy; s represents an integer from 0 to 4; R7 and R8 independently represent hydrogen, C1-6 alkyl or C3-8cycloalkyl; or solvates thereof.

Substituted arylamides

Substituted benzamide compounds are provided along with methods for the use of those compounds for treating cancer.

INHIBITORS OF HUMAN TUMOR-EXPRESSED CCXCKR2

Pharmaceutical compositions containing organic compounds or salts thereof that serve as modulators for the SDF-1 or I-TAC chemokines are disclosed. The compounds and compositions are useful in the treatment of cancer, especially in the inhibition of cancer proliferation, growth, and metastasis. Methods of interfering with SDF-1 and/or I-TAC binding to the CCXCKR2 receptor and treating cancer using the compounds and pharmaceutical compositions of the present invention are also disclosed.