929089-82-7

Basic information

• Product Name: [tert-butoxycarbonyl-(3-tert-butoxycarbonylamino-propyl)-amino]-acetic acid 1-methyl-2-phenyl-ethyl ester
• CAS NO: 929089-82-7
• Molecular Weight: 450.576
• Mol File: 929089-82-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [tert-butoxycarbonyl-(3-tert-butoxycarbonylamino-propyl)-amino]-acetic acid 1-methyl-2-phenyl-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [tert-butoxycarbonyl-(3-tert-butoxycarbonylamino-propyl)-amino]-acetic acid 1-methyl-2-phenyl-ethyl ester(929089-82-7)
• EPA Substance Registry System: [tert-butoxycarbonyl-(3-tert-butoxycarbonylamino-propyl)-amino]-acetic acid 1-methyl-2-phenyl-ethyl ester(929089-82-7)

Safety Data

• Hazardous Substances Data: 929089-82-7(Hazardous Substances Data)

Upstream product

• 1517-68-6 (S)-1-phenylpropan-2-ol 
• 192124-66-6 N,N'-bis(tert-butoxycarbonyl)-(3-aminopropyl)-glycine 
• 698-87-3 3-phenyl-2-propanol 

Relevant articles and documents

Enantioselective synthesis of 3-methylisochromans and determination of their absolute configurations by circular dichroism

Seven (S)-3-methylisochromans with different substitution patterns on their aromatic rings, and hence with different directions of their sum electric transition moments, were synthesized by ring-closure of optically active (S)-1-arylpropan-2-ol derivatives. The (S)-1-arylpropan-2-ols were obtained by kinetic resolution and their absolute configurations were determined with the aid of a zinc porphyrin tweezer and by Mosher's method. A systematic CD study of substituted isochroman derivatives revealed that, unlike in the cases of chiral tetralin and 2,3-dihydrobenzo[b]furan chromophores, the presence of achiral substituents of large spectroscopic moment (e.g., OMe) on the aromatic ring does not change the helicity rule of the "unsubstituted" isochroman chromophore: (P)/(M) helicity of the isochromen heteroring resulted in positive/negative 1Lb band Cotton effects (CE) regardless of the nature(s) and position(s) of the substituent(s). (S)-3-Methylisochromans were oxidized at C-1, allowing access to the corresponding dihydroisocoumarins, in which positive CE of the n→-π* transitions were correlated with (P) helicity and (S) absolute configuration. On DDQ-assisted oxidation, two trans-1-methoxy-3-methylisochrornan derivatives were prepared and used to study the effect of the axial benzylic C-1 methoxy group on the conformation of the heteroring and the 1Lb band CE. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.