929118-32-1

Basic information

• Product Name: Thiazole, 2-[4-(1-methylethoxy)phenoxy]-
• CAS NO: 929118-32-1
• Molecular Formula: C12H13NO2S
• Molecular Weight: 235.307
• Mol File: 929118-32-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Thiazole, 2-[4-(1-methylethoxy)phenoxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: Thiazole, 2-[4-(1-methylethoxy)phenoxy]-(929118-32-1)
• EPA Substance Registry System: Thiazole, 2-[4-(1-methylethoxy)phenoxy]-(929118-32-1)

Safety Data

• Hazardous Substances Data: 929118-32-1(Hazardous Substances Data)

Upstream product

• 106-51-4 p-benzoquinone 
• 3034-53-5 2-bromo-1,3-thiazole 
• 7495-77-4 4-isopropoxyphenol 

Downstream Products

• 929118-35-4 2-(4-isopropoxyphenoxy)-5-(tributylstannyl)thiazole 
• 929118-52-5 5-iodo-2-(4-isopropoxyphenoxy)thiazole 
• 903886-66-8 2-{3-[2-(4-isopropoxyphenoxy)thiazol-5-yl]-1-methyl-prop-2-ynyl}isoindole-1,3-dione 
• 903886-78-2 3-[2-(4-isopropoxyphenoxy)thiazol-5-yl]-1-methylprop-2-ynylamine 
• 929118-33-2 2-(4-isopropoxyphenoxy)-1,3-thiazole-5-carbaldehyde oxime 
• 929118-34-3 2-(4-isopropoxyphenoxy)thiazole-5-carbaldehyde 

Relevant articles and documents

NOVEL ACETYL-COA CARBOXYLASE (ACC) INHIBITORS AND THEIR USE IN DIABETES, OBESITY AND METABOLIC SYNDROME

The present invention relates to compounds of formula (I): Pharmaceutical compositions and methods that are useful in the treatment or prevention of metabolic diseases or conditions are also provided.

NOVEL ACETYL-COA CARBOXYLASE (ACC) INHIBITORS AND THEIR USE IN DIABETES, OBESITY AND METABOLIC SYNDROME

The present invention relates to compounds of formula (I), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.

The synthesis and structure-activity relationship studies of selective acetyl-CoA carboxylase inhibitors containing 4-(thiazol-5-yl)but-3-yn-2-amino motif: Polar region modifications

The structure-activity relationship study focused on the polar region of the HTS hit A-80040 (1) producing several series of potent and selective ACC2 inhibitors. The SAR suggests a compact lipophilic pocket that does not tolerate polar and ionic groups.