92917-44-7 Usage
General Description
N-(2,6-dimethylphenyl)-N-nitrosoformamide, also known as Amodiaquin, is a chemical compound used as an antimalarial medication. It is a nitrosourea derivative that has been shown to have potent activity against the Plasmodium falciparum parasite, which causes malaria. Amodiaquin works by inhibiting the formation of hemozoin, a toxic byproduct of hemoglobin digestion by the parasite. This disrupts the parasite's ability to survive and reproduce within the red blood cells of the host, ultimately leading to its death. While Amodiaquin has been widely used in the past, its use has diminished due to potential side effects, including hepatotoxicity and hemolytic anemia, as well as the development of drug resistance in some malaria-endemic regions.
Check Digit Verification of cas no
The CAS Registry Mumber 92917-44-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,2,9,1 and 7 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 92917-44:
(7*9)+(6*2)+(5*9)+(4*1)+(3*7)+(2*4)+(1*4)=157
157 % 10 = 7
So 92917-44-7 is a valid CAS Registry Number.
92917-44-7Relevant articles and documents
Studies on organophosphorus compounds. XLV. Thiation of some sterically hindered N-nitrosamides
Joergensen, Karl Anker,Ghattas, Abdul-Badik,Lawesson, Sven-Olov
, p. 204 - 208 (2007/10/02)
Some sterically hindered N-nitrosamides have been prepared using sodium nitrite in aqueous acid solution.Reaction of these N-nitrosamides with 2,4-bis-(4-methoxyphenyl)-1,2,3,4-dithiadiphosphetane-2,4-disulfide (Lawesson's Reagent ) causes thiation of both the carbonyl and the nitroso groups followed by destruction of the nitroso group giving ultimately the corresponding thioamides and amides as the main products.Dihydro-2(3H)-thiophenone is isolated as a by-product when N-nitroso-dihydro-2(3H)-pyrrolidinone is reacted with LR.A mechanism for its formation is postulated.Thiation of the sterically hindered amides yields the thioamide as rotamers which in two cases could be separated by column chromatography.Ames test has been performed for some of the compounds.
