929219-25-0

Basic information

• Product Name: 1,3-Dioxolane, 2-[4-(3-chloropropoxy)phenyl]-4,5-bis(4-fluorophenyl)-, (4R,5S)-rel-
• CAS NO: 929219-25-0
• Molecular Formula: C24H21ClF2O3
• Molecular Weight: 430.879
• Mol File: 929219-25-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,3-Dioxolane, 2-[4-(3-chloropropoxy)phenyl]-4,5-bis(4-fluorophenyl)-, (4R,5S)-rel-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dioxolane, 2-[4-(3-chloropropoxy)phenyl]-4,5-bis(4-fluorophenyl)-, (4R,5S)-rel-(929219-25-0)
• EPA Substance Registry System: 1,3-Dioxolane, 2-[4-(3-chloropropoxy)phenyl]-4,5-bis(4-fluorophenyl)-, (4R,5S)-rel-(929219-25-0)

Safety Data

• Hazardous Substances Data: 929219-25-0(Hazardous Substances Data)

Usage

Type of Compound

Complex organic compound

Dioxolane ring

A five-membered ring containing two oxygen atoms

Substituted phenyl rings

Two phenyl rings with different substituents

Chiral compound

Exhibits stereochemistry with non-superimposable mirror images

Stereochemistry

(4R,5S)-rel
R configuration at carbon 4
S configuration at carbon 5

3-chloropropoxy group

A propoxy group with a chlorine atom attached to the third carbon

4-fluorophenyl groups

Two phenyl rings with a fluorine atom at the para position (4th position)

Potential Reactivity

Due to the presence of a chlorine atom and multiple fluorine atoms

Pharmaceuticals

As a potential drug candidate or intermediate in drug synthesis

Agrochemicals

As a component in the development of new pesticides or herbicides

Materials Science

For the development of new materials with specific properties

Research and Development

Of interest for further investigation into its properties, reactivity, and potential applications

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 53458-16-5 1,2-bis(4-fluorophenyl)-2-hydroxyethan-1-one 
• 82625-25-0 4-(3-chloropropoxy)benzaldehyde 
• 119441-83-7 meso-1,2-bis(4-fluorophenyl)ethane-1,2-diol 

Relevant articles and documents

New 1,3-dioxolane and 1,3-dioxane derivatives as effective modulators to overcome multidrug resistance

Multidrug resistance (MDR) to antitumor agents represents a major obstacle to a successful chemotherapy of cancer. Overexpression of P-glycoprotein (p-gp) seems to be the major factor responsible for MDR. A large number of chemically unrelated compounds are known to interact with p-gp resulting in a decreasing resistance. In our efforts related to structure-activity studies of new potential MDR reversal agents we synthesized a series of compounds that differ in the aromatic core structure, the linker, and the basic moiety. For our search of new aromatic core structures we synthesized novel 2,2-diphenyl-1,3-dioxolane, 2,2- diphenyl-1,3-dioxane, and 4,5-diphenyl-1,3-dioxolane derivatives. A range of lipophilic linker structures and protonable basic moieties were synthesized and investigated to optimize the structure of the potential MDR-modulators. The compounds were tested in vitro using human Caco-2 cells. Both the cytotoxicity of the synthons and their ability to resensitize the cells were determined with a MTT assay. The results show that at low concentration various substances reverse tumor cell MDR. Some of the new structures show better effects than established modulators like trifluoperazine.