929568-19-4

Basic information

• Product Name: 2-AMino-1-Boc-iMidazole
• Synonyms: 2-AMino-1-Boc-iMidazole;tert-butyl 2-amino-1H-imidazole-1-carboxylate;2-amino-1-tert-butoxycarbonylimidazole
• CAS NO: 929568-19-4
• Molecular Formula: C8H13N3O2
• Molecular Weight: 183.20772
• Mol File: 929568-19-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2-AMino-1-Boc-iMidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMino-1-Boc-iMidazole(929568-19-4)
• EPA Substance Registry System: 2-AMino-1-Boc-iMidazole(929568-19-4)

Safety Data

• Hazardous Substances Data: 929568-19-4(Hazardous Substances Data)

Usage

General Description

2-Amino-1-Boc-Imidazole is a chemical compound with the molecular formula C8H15N3O2. It is an organic compound that is often used as a building block in the synthesis of various medications, including antiviral and anticancer drugs. The compound is a derivative of imidazole and features a Boc (tert-butoxycarbonyl) protective group on the amino group. Due to its versatile reactivity, it is commonly used in organic chemistry as a reagent in the production of pharmaceuticals, agrochemicals, and other fine chemicals. Its structural properties and reactivity make it valuable in the field of medicinal chemistry and drug development.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 42383-61-9 2-aminoimidazolesulfate 
• 7720-39-0 1H-imidazol-2-amine 

Downstream Products

• 1186299-71-7 2-(tert-butoxycarbonyl)amino-1-(tert-butoxycarbonyl)-1H-imidazole 

Relevant articles and documents

Design, synthesis, and evaluation of hinge-binder tethered 1,2,3-triazolylsalicylamide derivatives as Aurora kinase inhibitors

A series of hinge-binder tethered 1,2,3-triazolylsalicylamide derivatives were designed, synthesized, and evaluated for the Aurora kinase inhibitory activities. The novel hinge-binder tethered 1,2,3-triazolylsalicylamide scaffold was effectively assembled by Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition (CuAAC). A variety of alkynes with hinge binders were used to search proper structures-binding relationship to the hinge region. The synthesized 1,2,3-triazolylsalicylamide derivatives showed significant Aurora kinase inhibitory activity. In particular, 8a inhibited Aurora A kinase with an IC50 value of 0.284 μM, whereas 8m inhibited Aurora B kinase with an IC50 value of 0.364 μM.

PYRIMIDINE DERIVATIVES FOR THE INHIBITION OF IGF-IR TYROSINE KINASE ACTIVITY

A compound of formula (I) wherein the substituents are as defined in the text for use in inhibiting insulin-like growth factor 1 receptor activity in a warm blooded animal such as man.