92961-03-0

Basic information

• Product Name: 1,3-dichloro-7-nitro-9H-fluorene
• CAS NO: 92961-03-0
• Molecular Formula: C₁₃H₇Cl₂NO₂
• Molecular Weight: 280.1062
• Mol File: 92961-03-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 428.4°C at 760 mmHg
• Flash Point: 212.9°C
• Density: 1.521g/cm³
• Vapor Pressure: 3.81E-07mmHg at 25°C
• Refractive Index: 1.687
• CAS DataBase Reference: 1,3-dichloro-7-nitro-9H-fluorene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-dichloro-7-nitro-9H-fluorene(92961-03-0)
• EPA Substance Registry System: 1,3-dichloro-7-nitro-9H-fluorene(92961-03-0)

Safety Data

• Hazardous Substances Data: 92961-03-0(Hazardous Substances Data)

Usage

Type of compound

Nitro-substituted fluorene derivative

Parent compound

Fluorene (a polycyclic aromatic hydrocarbon)

Chlorine atoms

Attached to carbon atoms at positions 1 and 3

Nitro group

Present in the molecule

Usage

Research and industrial applications as a reagent or intermediate in the synthesis of other compounds

Chemical properties

Influenced by the presence of both nitro and chloro groups

Potential applications

Precursor in organic synthesis, reagent in chemical reactions

Importance

Significant in the field of organic chemistry and development of new materials and compounds

Upstream product

• 97028-17-6 1.3-Dichlor-7-nitro-2-fluorenamin 
• 72570-99-1 2-acetylamino-7-nitrofluorene 
• 899-87-6 N-2-(1.3-Dichlor-7-nitro-fluorenyl)-acetamid 

Downstream Products

• 93186-53-9 1,3-Dichlor-7-nitro-9-oxo-fluoren 

Relevant articles and documents

Synthesis and biological activities of aryl-ether-, biaryl-, and fluorene-aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT-2

Excitatory amino acid transporters (EAATs) play a pivotal role in maintaining glutamate homeostasis in the mammalian central nervous system, with the EAAT-2 subtype thought to be responsible for the bulk of the glutamate uptake in forebrain regions. A complete elucidation of the functional role of EAAT-2 has been hampered by the lack of potent and selective pharmacological tools. In this study, we describe the synthesis and biological activities of novel aryl-ether, biaryl-, and fluorene-aspartic acid and diaminopropionic acid analogs as potent inhibitors of EAAT-2. Compound (16) represents one of the most potent (IC50 = 85 ± 5 nM) and selective inhibitors of EAAT-2 identified to date.