929634-33-3

Basic information

• Product Name: ADAMTS-5
• Synonyms: ADAMTS-5 Inhibitor;(5Z)-5-[[5-[(4-chlorophenyl)methylsulfanyl]-1-methyl-3-(trifluoromethyl)pyrazol-4-yl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
• CAS NO: 929634-33-3
• Molecular Formula: C16H11ClF3N3OS3
• Molecular Weight: 449.9212496
• Mol File: 929634-33-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ADAMTS-5(CAS DataBase Reference)
• NIST Chemistry Reference: ADAMTS-5(929634-33-3)
• EPA Substance Registry System: ADAMTS-5(929634-33-3)

Safety Data

• Hazardous Substances Data: 929634-33-3(Hazardous Substances Data)

Usage

Uses

ADAMTS-5 Inhibitor is an inhibitor of ADAMTS-5 and has the potential of inhibiting the degredation of aggrecan, a major component of cartilage lost in osteoporosis.

Upstream product

• 141-84-4 2-thioxo-4-thiazolidinone 
• 6258-66-8 (4-chlorophenyl)methanethiol 
• 128455-62-9 5-chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde 

Relevant articles and documents

5-((1H-Pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5

A series of 5-((1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5 (aggrecanase-2) is described. These compounds show μM functional inhibition of ADAMTS-5, and represent a new class of agents with the potential of inhibiting degradation of aggrecan, a major component of cartilage which is lost in osteoporosis. Compound 12 is noteworthy in that it has an ADAMTS-5 IC50: 1.1 μM and shows >40-fold functional selectivity over ADAMTS-4 (aggrecanase-1).