92973-24-5

Basic information

• Product Name: 5-[2-(TRIFLUOROMETHYL)PHENYL]-2-FUROIC
• Synonyms: 5-[2-(TRIFLUOROMETHYL)PHENYL]-2-FUROIC;5-[2-(Trifluoromethyl)phenyl]-2-furoic acid 97%
• CAS NO: 92973-24-5
• Molecular Formula: C₁₂H₇F₃O₃
• Molecular Weight: 256.178
• Product Categories: API intermediates;Building Blocks;Furans;Heterocyclic Building Blocks
• Mol File: 92973-24-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 163-167 °C(lit.)
• Boiling Point: 372.9°C at 760 mmHg
• Flash Point: 179.3°C
• Appearance: /
• Density: 1.395g/cm³
• Vapor Pressure: 3.19E-06mmHg at 25°C
• Refractive Index: 1.511
• CAS DataBase Reference: 5-[2-(TRIFLUOROMETHYL)PHENYL]-2-FUROIC(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[2-(TRIFLUOROMETHYL)PHENYL]-2-FUROIC(92973-24-5)
• EPA Substance Registry System: 5-[2-(TRIFLUOROMETHYL)PHENYL]-2-FUROIC(92973-24-5)

Safety Data

• Hazard Codes: T
• Statements: 25-36/37/38-43
• Safety Statements: 26-36/37
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• Hazardous Substances Data: 92973-24-5(Hazardous Substances Data)

Usage

Description

5-[2-(TRIFLUOROMETHYL)PHENYL]-2-FUROIC is a chemical compound that serves as a reagent in the synthesis of various pharmaceutical agents. It is characterized by the presence of a trifluoromethylphenyl group attached to a furoic acid structure, which contributes to its unique chemical properties and potential applications in medicinal chemistry.

Uses

Used in Pharmaceutical Industry:
5-[2-(TRIFLUOROMETHYL)PHENYL]-2-FUROIC is used as a chemical reagent for the preparation of novel TRPV1 antagonists. These antagonists are of interest in the development of treatments for pain management and other conditions related to the transient receptor potential vanilloid 1 (TRPV1) channel.
Used in Antibacterial Agents Development:
5-[2-(TRIFLUOROMETHYL)PHENYL]-2-FUROIC is also utilized in the preparation of potent inhibitors targeting FeII and MnII E. coli Methionine Aminopeptidase. These inhibitors have potential applications as antibacterial agents, contributing to the development of new treatments for bacterial infections and addressing the growing concern of antibiotic resistance.

InChI:InChI=1/C12H7F3O3/c13-12(14,15)8-4-2-1-3-7(8)9-5-6-10(18-9)11(16)17/h1-6H,(H,16,17)

Upstream product

• 88-14-2 2-furanoic acid 
• 88-17-5 2-(trifluoromethyl)benzenamine 
• 773874-52-5 5-[2-(trifluoromethyl)phenyl]furan-2-carboxylic acid methyl ester 
• 1423-27-4 2-(trifluoromethyl)phenylboronic acid 
• 2527-99-3 methyl 5-bromo-2-furoate 
• 1899-24-7 5-bromo-2-furancarboxaldehyde 
• 94098-56-3 5-(2-Trifluoromethyl-phenyl)-furan-2-carbaldehyde 

Downstream Products

• 92973-13-2 5-(2-Trifluoromethyl-phenyl)-furan-2-carbonyl chloride 
• 92972-99-1 {[1-Chloro-1-[5-(2-trifluoromethyl-phenyl)-furan-2-yl]-meth-(Z)-ylidene]-amino}-acetic acid ethyl ester 
• 92973-20-1 {[5-(2-Trifluoromethyl-phenyl)-furan-2-carbonyl]-amino}-acetic acid ethyl ester 
• 92973-10-9 {5-[5-(2-Trifluoromethyl-phenyl)-furan-2-yl]-tetrazol-1-yl}-acetic acid ethyl ester 
• 92972-82-2 {5-[5-(2-Trifluoromethyl-phenyl)-furan-2-yl]-tetrazol-1-yl}-acetic acid 
• 1026532-28-4 C₁₇H₉ClF₃NO₃ 
• 1144110-85-9 C₂₂H₁₅F₃N₄OS₂ 
• 1202644-36-7 5-(2-trifluoromethyl-phenyl)-furan-2-carboxylic acid 3-fluoro-4-methanesulfonylamino-benzylamide 
• 1365714-36-8 3,4,5-trimethoxybenzyl 5-(2-trifluoromethylphenyl)-2-furoate 
• 1383581-69-8 N-hydroxy-5-(2-(trifluoromethyl)phenyl)furan-2-carboxamide 

Relevant articles and documents

Derivatives of (R)-3-(5-Furanyl)carboxamido-2-aminopropanoic Acid as Potent NMDA Receptor Glycine Site Agonists with GluN2 Subunit-Specific Activity

NMDA receptors mediate glutamatergic neurotransmission and are therapeutic targets due to their involvement in a variety of psychiatric and neurological disorders. Here, we describe the design and synthesis of a series of (R)-3-(5-furanyl)carboxamido-2-am

Hydroxamic Acids as Potent Inhibitors of FeII and MnII E. coli Methionine Aminopeptidase: Biological Activities and X-ray Structures of Oxazole Hydroxamate-EcMetAP-Mn Complexes

New series of acids and hydroxamic acids linked to five-membered heterocycles including furan, oxazole, 1,2,4- or 1,3,4-oxadiazole, and imidazole were synthesized and tested as inhibitors against the FeII, CoII, and MnII f

Synthesis of heterocycles from arylation products of unsaturated compounds: XVIII. 5-Arylfuran-2-carboxylic acids and their application in the synthesis of 1,2,4-thiadiazole, 1,3,4-oxadiazole, and [1,2,4]triazolo[3,4-b][1,3,4] thiadiazole derivatives

Arylation of furan-2-carboxylic acid or its methyl ester with arenediazonium chlorides in the presence of copper(II) chloride gave the corresponding 5-arylfuran-2-carboxylic acids or methyl 5-arylfuran-2- carboxylates. 5-Arylfuran-2-carbonyl chlorides rea