93007-74-0

Basic information

• Product Name: Acetamide, N-(2,2-diphenylethyl)-
• Synonyms: 2-Acetamino-1,1-diphenyl-aethan;HMS1546E01;N-Acetyl-2,2-diphenylethylamin
• CAS NO: 93007-74-0
• Molecular Formula: C16H17NO
• Molecular Weight: 239.317
• Mol File: 93007-74-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Acetamide, N-(2,2-diphenylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-(2,2-diphenylethyl)-(93007-74-0)
• EPA Substance Registry System: Acetamide, N-(2,2-diphenylethyl)-(93007-74-0)

Safety Data

• Hazardous Substances Data: 93007-74-0(Hazardous Substances Data)

Upstream product

• 3963-62-0 2,2-Diphenylethylamine 
• 75-36-5 acetyl chloride 
• 492-70-6 1,2-diphenyl-1,2-ethanediol 
• 71-43-2 benzene 
• 947-91-1 Diphenylacetaldehyde 
• 86-29-3 Diphenylacetonitrile 
• 4695-13-0 2,2-diphenylacetamide 
• 41401-03-0 diphenyl-acetaldehyde-oxime 
• 1722-89-0 N-(2,2-diphenylvinyl)acetamide 
• 108-24-7 acetic anhydride 

Downstream Products

• 21998-45-8 (+/-)-N-Acetyl-2--2-phenyl-aethylamin 
• 151724-11-7 1-(4-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)ethanone 
• 101280-01-7 N-(2,2-diphenyl-ethyl)-N-nitroso-acetamide 

Relevant articles and documents

Silica-supported polyphosphoric acid in the synthesis of 4-substituted tetrahydroisoquinoline derivatives

We report herein an application of an α-amidoalkylation reaction, as an alternative efficient synthesis of 4-aryl- and 4-methyl-1,2,3,4- tetrahydroisoquinoline derivatives. The amides required for this purpose would result from reaction of aminoacetaldehyde dimethylacetal with different substituted benzenes in polyphosphoric acid, followed by acylation of the obtained amines with different acid chlorides or sulfochlorides. We compared the cyclisation step using conventional (milieu of acetictrifluoracetic acid = 4:1) and solid supported reagents (SiO2/PPA), as recovered, regenerated and reused without loss of its activity catalyst. We found that in comparison to conventional methods, the yields of the reaction are greater and the reaction time is shorter.