93020-56-5

Basic information

• Product Name: 2-Thiazolamine, 4-(4-methylphenyl)-N-phenyl-
• CAS NO: 93020-56-5
• Molecular Formula: C16H14N2S
• Molecular Weight: 266.367
• Mol File: 93020-56-5.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 2-Thiazolamine, 4-(4-methylphenyl)-N-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiazolamine, 4-(4-methylphenyl)-N-phenyl-(93020-56-5)
• EPA Substance Registry System: 2-Thiazolamine, 4-(4-methylphenyl)-N-phenyl-(93020-56-5)

Safety Data

• Hazardous Substances Data: 93020-56-5(Hazardous Substances Data)

Upstream product

• 98475-04-8 1-(4-methylphenyl)-2-(p-tolylsulfonyloxy)ethanone 
• 103-85-5 monophenylthiourea 
• 619-41-0 4-(bromoacetyl)toluene 
• 96475-75-1 4‐methylacetophenone oxime acetate 
• 103-72-0 phenyl isothiocyanate 
• 43009-16-1 phenyldithiocarbamic acid triethylamine salt 
• 122-00-9 para-methylacetophenone 
• 1226922-89-9 C₅H₅N*C₇H₇NS₂ 
• 51034-34-5 potassium aniline dithiocarbamate 
• 1074-52-8 ammonium phenyldithiocarbamate 
• 18418-42-3 phenyl-dithiocarbamic acid; sodium salt 
• 542-11-0 aniline hydrobromide 
• 101862-33-3 2-bromo-4-p-tolyl-thiazole 

Downstream Products

• 2211-46-3 (1H-benzoimidazol-2-ylmethyl)-phenyl-(4-p-tolyl-thiazol-2-yl)-amine 

Relevant articles and documents

CuBr2 mediated synthesis of 2-Aminothiazoles from dithiocarbamic acid salts and ketones

In a one-pot procedure, CuBr2 has been used as a efficient desulfurizing agent in the synthesis of 2-aminothiazoles by the condensation of in situ-generated 1-substituted thioureas from their dithiocarbamic acid salts, with in situ-generated α-bromoketones from ketones. All reactions were carried out under optimized reaction conditions and gave the target products in 61–95% yield.

Copper-Catalyzed Coupling of Oxime Acetates with Isothiocyanates: A Strategy for 2-Aminothiazoles

A new strategy for 2-aminothiazoles is developed via the copper-catalyzed coupling of oxime acetates with isothiocyanates. Various 4-substituted and 4,5-disubstituted 2-aminothiazoles were formed smoothly under mild reaction conditions. This process involved copper-catalyzed N-O bond cleavage, activation of vinyl sp2 C-H bonds, and C-S/C-N bond formations. It is noteworthy that the oxime acetates were used not only as a substrate but also as a single oxidant.

Green approach: An efficient synthesis of 2,4-disubstituted-1,3-thiazoles and selenazoles in aqueous medium under ultrasonic irradiation

An efficient and rapid procedure for the synthesis of 2,4-disubstituted-1,3-thiazoles and selenazoles has been described by the reaction of α-bromoketones with thiourea, phenylthiourea and selenourea at ambient temperature in aqueous medium under ultrasonic irradiation. Analytically pure products were formed within 10-60 s in excellent yields. The advantageous features of this non-conventional methodology over conventional methods are the operational simplicity, easy handling, yield-enhancing, time-reducing, mild reaction conditions and no by-product production.