93041-44-2

Basic information

• Product Name: 3-(2-Methoxyphenyl)-5-methyl-2,3-dihydroisoxazole-4-carboxylic acid
• Synonyms: 3-(2-methoxyphenyl)-5-methyl-2,3-dihydroisoxazole-4-carboxylic acid
• CAS NO: 93041-44-2
• Molecular Formula: C₁₂H₁₁NO₄
• Molecular Weight: 235.24
• Mol File: 93041-44-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 362.6 °C at 760 mmHg
• Flash Point: 173.1 °C
• Appearance: /
• Density: 1.268 g/cm³
• Refractive Index: 1.563
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(2-Methoxyphenyl)-5-methyl-2,3-dihydroisoxazole-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-Methoxyphenyl)-5-methyl-2,3-dihydroisoxazole-4-carboxylic acid(93041-44-2)
• EPA Substance Registry System: 3-(2-Methoxyphenyl)-5-methyl-2,3-dihydroisoxazole-4-carboxylic acid(93041-44-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 93041-44-2(Hazardous Substances Data)

Usage

General Description

3-(2-Methoxyphenyl)-5-methyl-2,3-dihydroisoxazole-4-carboxylic acid is a chemical compound with a long, complex name. It belongs to the class of dihydroisoxazole carboxylic acids and is made up of a 2-methoxyphenyl group, a 5-methyl group, and a 2,3-dihydroisoxazole-4-carboxylic acid group. 3-(2-Methoxyphenyl)-5-methyl-2,3-dihydroisoxazole-4-carboxylic acid may have applications in the pharmaceutical industry, particularly in the development of new drugs or treatments. However, further research and analysis would be needed to fully understand its potential uses and effects.

InChI:InChI=1/C12H13NO4/c1-7-10(12(14)15)11(13-17-7)8-5-3-4-6-9(8)16-2/h3-6,11,13H,1-2H3,(H,14,15)

Upstream product

• 74467-01-9 2-methoxybenzohydroximoyl chloride 
• 105-45-3 acetoacetic acid methyl ester 
• 495417-30-6 ethyl 3-(2-methoxyphenyl)-5-methylisoxazole-4-carboxylate 
• 29577-53-5 2-Methoxy-benzaldehyde oxime 
• 135-02-4 ortho-anisaldehyde 
• 6609-56-9 2-methoxy-benzonitrile 

Downstream Products

• 92576-27-7 3-(2-methoxy-phenyl)-5-methyl-isoxazole-4-carboxylic acid amide 
• 1364523-75-0 (4-(5-amino-2-chloro-4-nitrophenyl)piperazin-1-yl)(3-(2-methoxyphenyl)-5-methylisoxazol-4-yl)methanone 
• 1364522-66-6 N-(4-chloro-5-(4-(3-(2-methoxyphenyl)-5-methylisoxazole-4-carbonyl)piperazin-1-yl)-2-nitrophenyl)-4-(2-oxopyrrolidin-1-yl)benzamide 
• 1364524-02-6 (4-(6-amino-3,5-dichloropyridin-2-yl)piperazin-1-yl)(3-(2-methoxyphenyl)-5-methylisoxazol-4-yl)methanone 
• 1364524-13-9 (4-(6-amino-3-chloro-5-nitropyridin-2-yl)piperazin-1-yl)(3-(2-methoxyphenyl)-5-methylisoxazol-4-yl)methanone 
• 1364523-79-4 (4-(5-amino-2,4-dichlorophenyl)piperazin-1-yl)(3-(2-methoxyphenyl)-5-methylisoxazol-4-yl)methanone 
• 1364523-88-5 2-amino-5-chloro-4-(4-(3-(2-methoxyphenyl)-5-methylisoxazole-4-carbonyl)piperazin-1-yl)benzonitrile 
• 1364523-95-4 4-amino-5-chloro-2-(4-(3-(2-methoxyphenyl)-5-methylisoxazole-4-carbonyl)piperazin-1-yl)benzonitrile 
• 1364523-98-7 (4-(5-amino-2-chloro-4-vinylphenyl)piperazin-1-yl)(3-(2-methoxyphenyl)-5-methylisoxazol-4-yl)methanone 
• 1370420-79-3 (4-(5-amino-2-bromo-6-nitropyridin-3-yl)piperazin-1-yl)(3-(2-methoxyphenyl)-5-methylisoxazol-4-yl)methanone 
• 1370420-75-9 (4-(2-bromo-6-nitropyridin-3-yl)piperazin-1-yl)(3-(2-methoxyphenyl)-5-methylisoxazol-4-yl)methanone 

Relevant articles and documents

Design, synthesis and in vitro biological evaluation of isoxazol-4-carboxa piperidyl derivatives as new anti-influenza A agents targeting virus nucleoprotein

Influenza infection is a major cause of morbidity and mortality during seasonal epidemics and sporadic pandemics. It is important and urgent to develop new anti-influenza agents with a new mechanism of action. Nucleozin has been reported as a potent antagonist of nucleoprotein accumulation in the nucleus. In this study, a new series of isoxazol-4-carboxa piperidyl derivatives 1a-j were synthesized and their chemical structures were confirmed by 1H, 13C NMR and mass spectral data. Furthermore, all the synthesized compounds were evaluated for in vitro anti-influenza virus activity against influenza virus (A/PR/8/34 H1N1). Among all the compounds, 1a, 1b, 1c, 1f and 1g exhibited more potent activity than the standard drug, and compound 1b has showed most promising anti-influenza virus activity. These results are also consistent with the docking study results in terms of the design of compounds targeting influenza A via viral nucleoprotein.

NOVEL PIPERAZINE ANALOGS WITH SUBSTITUTED HETEROARYL GROUPS AS BROAD-SPECTRUM INFLUENZA ANTIVIRALS

A compound of the following Formula (I) is set forth, including pharmaceutically acceptable salts thereof: wherein Het is a 5 or 6-membered heterocycle with -N, -O, or -S adjacent to the -Ar substituent or adjacent to the point of attachment for the -Ar substituent; Ar is aryl or heteroaryl; R is -CH3, -CH2F, -CHF2 or -CH=CH2; V is -H, -CH3 or =0; W is -NO2, -CI, -Br, -CH2OH, or -CN; X is -CI, -Br, -F, -CH3, -OCH3, or -CN; Y is -CH or -N; and Z is -CH or -N. This compound is useful in compositions for the prevention and treatment of influenza virus.

Isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists

This Letter describes the synthesis and evaluation of mGluR7 antagonists in the isoxazolopyridone series. In the course of modification in this class, novel solid support synthesis of the isoxazolopyridone scaffold was developed. Subsequent chemical modification led to the identification of several potent derivatives with improved physicochemical properties compared to a hit compound 1. Among these, 2 showed good oral bioavailability and brain penetrability, suggesting that 2 may be useful for in vivo study to elucidate the role of mGluR7.