93102-92-2Relevant articles and documents
Rhodium-mediated asymmetric transfer hydrogenation: A diastereo- and enantioselective synthesis of: Syn -α-amido β-hydroxy esters
Zheng, Long-Sheng,Férard, Charlène,Phansavath, Phannarath,Ratovelomanana-Vidal, Virginie
supporting information, p. 283 - 286 (2018/01/12)
The preparation of syn α-benzoylamido β-hydroxy esters through asymmetric transfer hydrogenation (ATH) with a tethered Rh(iii)-DPEN complex via dynamic kinetic resolution (DKR) has been developed for the first time starting from α-benzoylamido β-keto esters. A variety of α-benzoylamido β-keto esters were converted under mild conditions into the corresponding syn α-benzoylamino β-hydroxy esters with high yields (up to 98%) and diastereomeric ratios (up to >99:1 dr) as well as excellent enantioselectivities (up to >99% ee).
Dynamic kinetic resolution catalyzed by Ir axially chiral phosphine catalyst: Asymmetric synthesis of anti aromatic β-hydroxy-α-amino acid esters
Makino, Kazuishi,Hiroki, Yasuhiro,Hamada, Yasumasa
, p. 5784 - 5785 (2007/10/03)
The anti selective hydrogenation of α-amino-β-keto esters via dynamic kinetic resolution was achieved for the first time by using the iridium-MeOBIPHEP catalyst in asymmetric synthesis of anti aromatic β-hydroxy-α-amino acid esters with excellent diastereo- and enantioslectivities. Acetic acid as a solvent and sodium acetate as an additive affected dramatically the yield and the enantioselectivity, respectively. The product anti aromatic β-hydroxy-α-amino acid esters are useful for synthesis of pharmaceuticals and natural products. Copyright
