931105-37-2

Basic information

• Product Name: Methyl 5-bromo-2-fluoronicotinate
• Synonyms: Methyl 5-bromo-2-fluoronicotinate;Methyl 5-broMo-2-fluoropyridine-3-carboxylate;5-Bromo-2-fluoro-3-pyridinecarboxylic acid methyl ester
• CAS NO: 931105-37-2
• Molecular Formula: C₇H₅BrFNO₂
• Molecular Weight: 234.023
• Mol File: 931105-37-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 260.6°C at 760 mmHg
• Flash Point: 111.4°C
• Appearance: /
• Density: 1.66g/cm³
• Vapor Pressure: 0.0121mmHg at 25°C
• Refractive Index: 1.533
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: Methyl 5-bromo-2-fluoronicotinate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 5-bromo-2-fluoronicotinate(931105-37-2)
• EPA Substance Registry System: Methyl 5-bromo-2-fluoronicotinate(931105-37-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 931105-37-2(Hazardous Substances Data)

Usage

General Description

Methyl 5-bromo-2-fluoronicotinate is an organic compound with the formula C8H6BrFNO2. It is a derivative of nicotinic acid and belongs to the class of pyridines. This chemical is commonly used in the pharmaceutical industry for the synthesis of various pharmaceutical products. Methyl 5-bromo-2-fluoronicotinate is known for its potential biological activities and therapeutic properties, making it a valuable building block in drug discovery and development. Its unique structure and properties make it an important intermediate in the synthesis of various pharmaceutical compounds.

InChI:InChI=1/C7H5BrFNO2/c1-12-7(11)5-2-4(8)3-10-6(5)9/h2-3H,1H3

Upstream product

• 78686-79-0 methyl 2-chloro-5-bromonicotinate 
• 29241-66-5 5-bromo-2-fluoro-pyridine-3-carboxylic acid 
• 74-88-4 methyl iodide 
• 18107-18-1 diazomethyl-trimethyl-silane 

Downstream Products

• 29241-66-5 5-bromo-2-fluoro-pyridine-3-carboxylic acid 
• 115891-38-8 methyl 5-bromo-2-phenylaminopyridine-3-carboxylate 
• 1622217-20-2 methyl 2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate 

Relevant articles and documents

2-AMINO-N-PHENYL-NICOTINAMIDES AS NAV1.8 INHIBITORS

Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.

Structure-Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]Pyridin-2-one-Based p38 MAP Kinase Inhibitors: Part 2

We identified novel potent inhibitors of p38 mitogen-activated protein (MAP) kinase using a structure-based design strategy, beginning with lead compound, 3-(butan-2-yl)-6-(2,4-difluoroanilino)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one (1). To enhance the inhibitory activity of 1 against production of tumor necrosis factor-α (TNF-α) in human whole blood (hWB) cell assays, we designed and synthesized hybrid compounds in which the imidazo[4,5-b]pyridin-2-one core was successfully linked with the p-methylbenzamide fragment. Among the compounds evaluated, 3-(3-tert-butyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-4-methyl-N-(1-methyl-1H-pyrazol-3-yl)benzamide (25) exhibited potent p38 inhibition, superior suppression of TNF-α production in hWB cells, and also significant in vivo efficacy in a rat model of collagen-induced arthritis (CIA). In this paper, we report the discovery of potent, selective, and orally bioavailable imidazo[4,5-b]pyridin-2-one-based p38 MAP kinase inhibitors.

SUBSTITUTED GUANIDINE DERIVATIVE

The present invention provides a compound of general formula (I) (wherein, R1, X, p and q are as described in the present description and claims), or a pharmacologically acceptable salt thereof, and a pharmaceutical composition containing that compound.