93138-64-8

Basic information

• Product Name: N′-(3-methylbutan-2-yl)benzohydrazide
• Synonyms: N′-(3-methylbutan-2-yl)benzohydrazide
• CAS NO: 93138-64-8
• Molecular Weight: 206.288
• Mol File: 93138-64-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N′-(3-methylbutan-2-yl)benzohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: N′-(3-methylbutan-2-yl)benzohydrazide(93138-64-8)
• EPA Substance Registry System: N′-(3-methylbutan-2-yl)benzohydrazide(93138-64-8)

Safety Data

• Hazardous Substances Data: 93138-64-8(Hazardous Substances Data)

Upstream product

• 75-30-9 2-iodo-propane 
• 1483-22-3 N'-ethylidenebenzohydrazide 
• 598-75-4 3-methyl-2-butanol 
• 613-94-5 benzoic acid hydrazide 

Relevant articles and documents

Nickel-Catalyzed N-Alkylation of Acylhydrazines and Arylamines Using Alcohols and Enantioselective Examples

A borrowing-hydrogen reaction between amines and alcohols is an atom-economic way to prepare alkylamines, ideally with water as the sole byproduct. Herein, nickel catalysts are used for direct N-alkylation of hydrazides and arylamines using racemic alcohols. Moreover, a nickel catalyst of (S)-binapine was used for an asymmetric N-alkylation of benzohydrazide with racemic benzylic alcohols.

Method for preparing secondary amine or N'-alkyl hydrazide through nickel catalysis N-alkylation reaction

The invention discloses a method for preparing secondary amine or N'-alkyl hydrazide through nickel catalysis N-alkylation reaction. Amine or hydrazide is used as raw materials; alcohol is used as an alkylation agent; N-alkylation reaction is performed under the nickel catalysis condition; the secondary amine or N'-alkyl hydrazide is prepared. Compared with the prior art, the method provided by the invention has the advantages that the N-alkylation reaction is performed; active catalysts can be generated in situ by nickel salt and phosphine ligands; the preparation of catalysts in advance is avoided; the operation is simple and convenient; the experiment steps and the experiment cost are reduced. Cheap nickel is used as the catalysts; the consumption of the catalysts is low; the use of expensive and high-toxicity precious metal is avoided; the experiment cost is further reduced; the hydrogen borrowing strategy is utilized; the N'-alkylation of the hydrazide is realized for the first time; byproducts only contain water. Compared with other preparation methods, the method has the advantage that the reaction environment-friendly performance is realized.